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Principal Scientist
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Cambridge, United States Nuvalent, Inc Full timeReporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least...
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Principal Scientist
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Principal Scientist
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Principal Scientist
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Principal Scientist
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Principal Scientist, Protein Production
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Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Cambridge, United States Flagship Pioneering Full timeCompany Summary: Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as > 95% of global healthcare costs are spent on treating rather than preventing...
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Principal Scientist, Protein Production
3 months ago
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Principal Scientist, Protein Production
3 months ago
Cambridge, United States Repertoire Immune Medicines Full timeJob DescriptionJob DescriptionPrincipal Scientist, Protein Production and Process DevelopmentCompany OverviewRepertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the...
Principal Scientist
2 months ago
Beacon Hill Life Sciences is actively recruiting for a Senior Scientist / Principal Scientist to work a contract assignment. The Senior Scientist / Principal Scientist will be able to follow programs as they proceed through development as supporting the overall drug substance development and manufacturing activities. The successful candidate needs to demonstrate a proven track record of solving technical challenges while supporting GMP manufacturing.
Location: Cambridge, MA
Duration: At least 6 months, possible extension.
Pay Rate: Based on experience (+$60/hour)
Key Responsibilities
- Solve technical issues related to drug substance manufacturing by providing hands-on laboratory support within the chemical development group including process design, optimization, scale-up, process intensification, process characterization, and spike-and-purge studies to bring a clinical phase program to commercial readiness.
- Work with external CMO/CRO teams to enhance/support their laboratory experimentation.
- Author internal technical reports based on in-house laboratory research and provide critical review of similar reports generated at external CMO/CROs.
- Identify key knowledge gaps and execute plans to ensure process understanding is commensurate with a given program’s stage of clinical development.
Minimum Requirements
- In-depth knowledge of Synthetic Organic Chemistry.
- MS or PhD in organic chemistry with 5+ years (MS) or 3+ years (PhD) of industry experience.
- Demonstrated laboratory experience developing processes to produce small molecule pharmaceuticals from early to late-stage development.
- Ability to navigate and be successful in a fast-paced, highly-matrixed work environment.
- Effective verbal and written communication skills.
- Demonstrated experience with organic chemistry instrumentation and interpretation including HPLC, LCMS, GC, NMR, and applicable software (ChemDraw, Excel, Word, PowerPoint).
- Demonstrated proficiency to manage timelines by effective prioritization to meet project goals.
Preferred Qualifications
- Working knowledge with DSC, TGA, and XRPD instrumentation and familiarity with Mettler‑Toledo equipment are preferred.
- Demonstrated scientific contribution to the synthetic community evidenced by presentations and publications.
- Regulatory writing experience including IND/IMPD/NDA/MAA drug substance quality modules.
Beacon Hill is an Equal Opportunity Employer that values the strength diversity brings to the workplace. Individuals with Disabilities and Protected Veterans are encouraged to apply.
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