Current jobs related to Principal Scientist - Cambridge - Planet Pharma
-
Senior/Principal Scientist, Biology
1 week ago
Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Our approach...
-
Principal Scientist Upstream
4 weeks ago
Cambridge, Massachusetts, United States GSK LLP Full timeJob Title: Principal Scientist UpstreamGSK is seeking a highly motivated and experienced Principal Scientist Upstream to join our mRNA Drug Substance team in Cambridge, MA. As a key member of our team, you will play a critical role in shaping our mRNA vaccine platforms to accelerate the development of new vaccine candidates.Key Responsibilities:Design,...
-
Principal Scientist
2 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeAbout the Role:We are seeking a highly motivated and experienced Principal Scientist to join our interdisciplinary team at Novartis. As a key member of our team, you will be responsible for proposing, designing, and evaluating novel assays and chemotypes to tackle longstanding challenges in covalent ligand discovery.Key Responsibilities:Design and evaluate...
-
Principal Scientist Immunology
1 month ago
Cambridge, Massachusetts, United States Flagship Ventures Full timeImmunology Research ScientistFlagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. We are seeking a highly skilled PhD level Principal Scientist with proven experience in immunology and preclinical research to join our team.Key...
-
Principal NLP Machine Learning Scientist
1 month ago
Cambridge, Massachusetts, United States DeepRec Full timeJob Title: Principal NLP Machine Learning ScientistWe are seeking a highly skilled Principal NLP Machine Learning Scientist to join our innovative team at DeepRec in Cambridge, Massachusetts.Key Responsibilities:Develop and train large-scale language models using cutting-edge techniques and technologies.Collaborate with cross-functional teams to integrate...
-
Principal Scientist II, Emerging Technologies
3 weeks ago
Cambridge, Massachusetts, United States Advanced Accelerator Applications (Italy) - S... Full timeJob Title: Principal Scientist II, Emerging TechnologiesWe are seeking an innovative and dynamic Principal Scientist II with extensive expertise in neuroscience and animal behavior to join our Emerging Technologies team in Comparative Medicine. This team focuses on exploring in vivo digital biomarkers using state-of-the-art, non-invasive technologies such as...
-
Principal NLP Machine Learning Scientist
5 months ago
Cambridge, United States DeepRec.ai Full timePrincipal Machine Learning Scientist (Large Language Models)Location: Hybrid in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.You will be part of an agile, cross-functional team responsible for...
-
Senior Principal Scientist, Pharmacology
4 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeAbout the Role:The Novartis Group of Companies is seeking a highly skilled and experienced Senior Principal Scientist to join our team in Cambridge, MA. As a key member of our dynamic and multi-disciplinary team, you will play a critical role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery...
-
Principal Scientist, Protein Production
3 months ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Principal Scientist, Protein Production
4 weeks ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Principal Scientist, Protein Production
3 months ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Principal Scientist, Protein Sciences
3 days ago
Cambridge, Massachusetts, United States Flagship Ventures Full timeRole SummaryFlagship Ventures is seeking a dedicated and skilled Principal Scientist, Protein Sciences to join our team. The role will focus on peptide or antibody production, discovery, and engineering through hit optimization and lead identification.Key ResponsibilitiesLead and manage projects focused on peptide or antibody production, discovery, and...
-
Cambridge, Massachusetts, United States Flagship Pioneering Full timeCompany Overview:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. With a proven track record of success, Flagship has originated and fostered over 100 scientific ventures, resulting in over $90 billion in aggregate...
-
Principal Scientist Nucleic Acid Medicine
1 month ago
Cambridge, Massachusetts, United States Evonik Degussa Corporation Full timeJob OpportunityWe are seeking a highly skilled and motivated individual to join our team as a Principal Scientist Nucleic Acid Medicine. This role is located onsite at our Cambridge, MA location.ResponsibilitiesEstablish and grow the Cell Culture team within the facility, driving recruitment efforts to assemble a talented team and foster a high-performance...
-
Senior/Principal Scientist, Biology
4 weeks ago
Cambridge, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...
-
Senior/Principal Scientist, Biology
1 week ago
cambridge, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...
-
Senior/Principal Scientist, Biology
1 week ago
Cambridge, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...
-
Senior/Principal Scientist, Biology
3 weeks ago
Cambridge, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...
-
Senior/Principal Scientist, Biology
4 weeks ago
Cambridge, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...
-
Senior/Principal Scientist, Biology
4 weeks ago
Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full timeAbout the OpportunityCrossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell...
Principal Scientist
2 months ago
Principal Scientist, Protein Production & Process Development
Priority Must Haves:
- Refolded E. coli experience (Ideal)
- If no E. Coli experience, must have
- Experience w/ Recombinant protein
- Experience with bispecific protein products
- Strong process development background
- Tech Transfer experience - working with CDMO
- Strong Communication and Leadership experience. Must have previous management experience and ability to speak to management style
NOTES:
- Candidates have fallen short due to lack of E Coli / Recombinant Protein, Bispecific experience
- Mammalian background is not enough
- This is a new role as they work to move into the clinic, building out tech transfer to CDMO to scale process
- Bispecifics and ecoli refolding - E Coli refolding is unique, most haven't done it sense academia.
- This person will be leading a team performing E.Coli refolding
- Strong leadership and communication skills needed
- Bispecific / Trispecific experience is good
- Team size - 3 FTE's, Sci;
- Management experience - Tell me about a time direct report wasn't performing and you needed to step in
- Really positive, leave ego at the door, help colleagues
- Management loves large pharma, believes that to be training ground; but makes for tough transition - small company experience ideal
- Protein biologics,
- E coli refolding
- Bispecifics / recombinant protein
- few years will suffice
- Open to NE relocation
- downstream - Sci 1 that manages 2 other individuals,
- Building out CMC model, hiring VP.
- This person will report into VP CMC, which they're currently hiring for. JOanna Swain, SVP Protein Eng, is the HM on this role now
- Currently securing CDMO
- PhD required
- Not looking for jumpy, Very sensitive to this, technical knowledge, polish - ability articulate the science and story;
- Flagship Pioneering benefits;
- no 401k match right now; offer equity - great time to join
Location: Cambridge, MA
Salary: around $180K
Role Overview
We are seeking an experienced Protein Production and Process Development leader with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes. The selected candidate and his/her/their team will work in a highly dynamic and cross-functional environment to facilitate seamless technology transfer to an external contract development and manufacturing organization (CDMO). The incumbent will also enable Repertoire’s proprietary platform technologies with high quality pMHC products produced by microbial or mammalian systems. The incumbent will interface with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to provide protein reagents and protein leads, including data packages supporting Development Candidate nomination.
Key Responsibilities
Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.
Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.
Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
Drive team engagement, ownership, and agility to deliver ambitious results.
Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.
Qualifications/Experience
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years’ experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Experience in research strategy development and operational management of research outcomes through cross-functional and outsourced teams, as well as budget planning and management.
- Technical report writing for inclusion in regulatory submissions.
- Desirable to have experience with bispecific protein products.
- Ability to drive strategic discussions with senior level management and external partners.
- Experience in building practical creativity in teams to persist and respond positively to changes.
- Experience in collaborating across teams to resolve problems with strategic and operational impact on individual, function, and corporate performance.
