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Principal Scientist, Protein Production
1 month ago
613284
Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes.
Required Skills:
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Strong process development background
- Experience with Recombinant protein
- Experience with bispecific protein products
Responsibilities:
- Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
- Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.
- Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.
- Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
- Drive team engagement, ownership, and agility to deliver ambitious results.
- Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.
Compensation within this range will be commensurate with level of experience
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