Principal Scientist

3 weeks ago


Cambridge, United States Planet Pharma Full time

Principal Scientist

  • Location: Cambridge, MA
  • Salary: $160-180K + equity
  • Open to relocation within the Northeast.


Required Skills:

  1. Expertise in downstream processing.
  2. Experience with microbial and mammalian systems.
  3. Experience in refolding E. coli proteins is highly desirable.
  4. If E. coli experience is not available, candidates must have experience with recombinant proteins and bispecific protein products.
  5. Strong background in process development.
  6. Proven experience in technology transfer and working with CDMOs.
  7. Excellent communication and leadership skills, including prior management experience and the ability to effectively convey management style.


Position Overview

We are looking for an accomplished leader in Protein Production and Process Development with significant experience in both microbial and mammalian production systems. The ideal candidate will have expertise in refolding E. coli proteins and a strong background in recombinant and bispecific protein products. This role demands a leader who excels in process development, technology transfer, and team management, especially in a high-growth and dynamic environment.


Key Responsibilities

  • Develop and optimize upstream and downstream processes for TCR bispecific molecules, ensuring a seamless technology transfer to contract manufacturing organizations (CDMOs).
  • Oversee the production and process development of novel pMHC reagents to support target identification, validation, and TCR affinity maturation.
  • Manage the technology transfer process, including transferring analytical methods to external CROs/CDMOs, providing training, troubleshooting, and technical support as needed.
  • Lead a team of research associates and scientists, fostering engagement, ownership, and agility to achieve ambitious goals.
  • Prepare and review technical documents and reports for CMC regulatory filings.
  • Collaborate with internal teams and external partners to provide protein reagents, data packages, and support for Development Candidate nomination.


Required Qualifications

  • PhD in Biochemistry, Biology, Bioengineering, Immunology, or a related field.
  • At least 8 years of experience in the pharma/biotech industry, with a strong background in process development and team management.
  • Demonstrated experience in refolding proteins from E. coli and managing proteins expressed in mammalian cells, including oversight of both upstream and downstream processes.
  • Proven ability to lead and manage lab teams, drive functional and corporate goals, and handle complex programs.
  • Experience with bispecific protein products is highly desirable.
  • Strong technical report writing skills, especially for regulatory submissions.
  • Proven experience in strategic discussions with senior management and external partners.
  • Ability to foster practical creativity within teams and respond positively to changes.

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