Principal Scientist
1 month ago
- Reporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.
- The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least one early-stage project operating under a virtual/CRO model.
- As a member of a small team, the Principal Scientist is expected to execute across all aspects of medicinal chemistry.
- Further, the scientist will be responsible for external CRO team management and interfacing with Nuvalent's internal biology, computational chemistry, and DMPK teams.
- The ideal candidate is well-versed and experienced in organic synthesis and medicinal chemistry; has experience managing chemistry outsourcing; and has exceptional written and oral communication skills, interpersonal skills, and critical thinking skills.
- Drive medicinal chemistry efforts and structure-based drug discovery on kinase projects: designing high quality small molecules to enable and progress projects, from hit identification to candidate
- Ph. D. in organic chemistry with 7 years of hands-on Medicinal Chemistry experience in the (bio)pharmaceutical industry
- Sound knowledge of related disciplines (DMPK, biology, tox, )
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Principal Scientist
1 month ago
Cambridge, Massachusetts, United States Nuvalent, Inc Full timeReporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least...
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Cambridge, Massachusetts, United States Proclinical Full timePrincipal Associate Scientist for Analytical Development - Contract - Cambridge, MA Proclinical is actively seeking a Principal Associate Scientist. This is a temporary contract position based in Cambridge, Massachusetts, MA. Primary Responsibilities:This role is primarily focused on the initial characterization testing, annual re-qualification, and trending...
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Principal Scientist
5 days ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryWe are seeking an experienced Senior Principal Scientist or Principal Scientist to join our Oncology Research and Development team at Novartis Group Companies. The successful candidate will be responsible for developing and implementing pharmacokinetics and clinical pharmacology strategies to support the development of innovative medicines.Key...
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Principal Scientist
1 week ago
Cambridge, United States Planet Pharma Full timePrincipal Scientist, Protein Production & Process DevelopmentPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must haveExperience w/ Recombinant proteinExperience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must...
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Principal Scientist
5 days ago
cambridge, United States Planet Pharma Full timePrincipal Scientist, Protein Production & Process DevelopmentPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must haveExperience w/ Recombinant proteinExperience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must...
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Principal Scientist
1 month ago
Cambridge, United States Planet Pharma Full timePrincipal Scientist, Protein Production & Process DevelopmentPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must haveExperience w/ Recombinant proteinExperience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must...
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Principal Scientist
3 weeks ago
Cambridge, United States Planet Pharma Full timePrincipal ScientistLocation: Cambridge, MASalary: $160-180K + equity Open to relocation within the Northeast.Required Skills: Expertise in downstream processing.Experience with microbial and mammalian systems.Experience in refolding E. coli proteins is highly desirable.If E. coli experience is not available, candidates must have experience with recombinant...
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Principal Scientist
3 weeks ago
Cambridge, United States Planet Pharma Full timePrincipal ScientistLocation: Cambridge, MASalary: $160-180K + equity Open to relocation within the Northeast.Required Skills: Expertise in downstream processing.Experience with microbial and mammalian systems.Experience in refolding E. coli proteins is highly desirable.If E. coli experience is not available, candidates must have experience with recombinant...
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Principal NLP Machine Learning Scientist
1 month ago
Cambridge, United States DeepRec.ai Full timePrincipal Machine Learning Scientist (Large Language Models)Location: Hybrid in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.You will be part of an agile, cross-functional team responsible for...
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Principal NLP Machine Learning Scientist
3 months ago
Cambridge, United States DeepRec.ai Full timePrincipal Machine Learning Scientist (Large Language Models)Location: Hybrid in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.You will be part of an agile, cross-functional team responsible for...
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Principal NLP Machine Learning Scientist
1 day ago
Cambridge, Massachusetts, United States DeepRec Full timeJob Title: Principal NLP Machine Learning ScientistAbout the Role:We are seeking a highly skilled Principal Machine Learning Scientist to join our team at DeepRec. As a key member of our team, you will be responsible for developing and training large-scale language models, fine-tuning models with feedback, and integrating multimodal scientific data.Key...
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Principal Scientist
2 days ago
Cambridge, Massachusetts, United States Bristol-Myers Squibb Full timeAbout the RoleBristol-Myers Squibb is seeking a highly skilled Principal Scientist to join our Computational Design and Predictive Modeling team in Cambridge, MA. As a key member of our team, you will play a critical role in developing novel bioinformatics and machine learning solutions to analyze and characterize antibody repertoire sequencing data.Key...
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Principal Scientist in Drug Development
5 days ago
Cambridge, Massachusetts, United States Newton Colmore Full timeAbout the RoleWe are seeking a highly experienced Senior DMPK and ADME Expert to join our research team at Newton Colmore. As a Principal Scientist in Drug Development, you will play a key role in designing and implementing in vivo PK studies, providing updates and results to research teams, and presenting strategies at governance interactions.Key...
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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Senior Principal Scientist
1 day ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryAs a Senior Principal Scientist in the Translational Medicine Drug Disposition Bioanalytical group at Novartis Group Companies, you will have the opportunity to make a significant impact in the development of novel modality biologics. This vital leadership role requires a collaborative nature, a commitment to teamwork, and a relentless focus on...
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Process Development Senior Principal Scientist
3 months ago
Cambridge, Massachusetts, United States Amgen Full timeHOW MIGHT YOU DEFY IMAGINATION?If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better...
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Principal LLM Machine Learning Scientist
3 months ago
Cambridge, United States DeepRec.ai Full timeMachine Learning Scientist (Large Language Models)Location: Onsite in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.Key Responsibilities:Fine-tune, scale, and deploy large language models on...
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Principal LLM Machine Learning Scientist
3 months ago
Cambridge, United States DeepRec.ai Full timeMachine Learning Scientist (Large Language Models)Location: Onsite in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.Key Responsibilities:Fine-tune, scale, and deploy large language models on...
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Cambridge, United States Flagship Pioneering Full timeCompany Summary: Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as > 95% of global healthcare costs are spent on treating rather than preventing...