Principal Scientist

1 month ago


Cambridge, United States Nuvalent, Inc Full time
  • Reporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.
  • The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least one early-stage project operating under a virtual/CRO model.
  • As a member of a small team, the Principal Scientist is expected to execute across all aspects of medicinal chemistry.
  • Further, the scientist will be responsible for external CRO team management and interfacing with Nuvalent's internal biology, computational chemistry, and DMPK teams.
  • The ideal candidate is well-versed and experienced in organic synthesis and medicinal chemistry; has experience managing chemistry outsourcing; and has exceptional written and oral communication skills, interpersonal skills, and critical thinking skills.
  • Drive medicinal chemistry efforts and structure-based drug discovery on kinase projects: designing high quality small molecules to enable and progress projects, from hit identification to candidate
  • Ph. D. in organic chemistry with 7 years of hands-on Medicinal Chemistry experience in the (bio)pharmaceutical industry
  • Sound knowledge of related disciplines (DMPK, biology, tox, )

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