Current jobs related to Principal Institute Research Scientist Medicinal Chemistry - Houston, Texas - University of Texas MD Anderson Cancer Center

  • Principal Research Scientist Medicinal Chemistry

    1 week ago

    Houston, Texas, United States MD Anderson Cancer Center Full time

    Job Title: Principal Research Scientist Medicinal ChemistryThis is a critical role at MD Anderson Cancer Center, where you will lead cross-functional research to discover lead molecules for progression into novel oncology therapeutic agents that benefit patients. As a highly creative synthetic chemist, you will be responsible for the design, optimization,...

  • Institute Research Scientist Cell Biology

    6 days ago

    Houston, Texas, United States MD Anderson Cancer Center Full time

    Job Title: Research Scientist Cell BiologyWe are seeking a highly motivated and talented Research Scientist to join our Reverse Translation group at the MD Anderson Cancer Center. As a key team member, you will be responsible for developing and independently leading research activities to advance projects from target validation through preclinical...

  • Research Scientist

    2 weeks ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Job SummaryHouston Methodist Academic Institute is seeking a highly skilled Research Scientist to join our team. As a Research Scientist, you will be responsible for providing technical support for laboratory-based research, working under the direction of a Principle Investigator (PI). Your duties will include supporting bench techniques, working with...

  • Senior Research Scientist in Planetary Studies

    4 weeks ago

    Houston, Texas, United States Universities Space Research Association Full time

    Position OverviewThe Universities Space Research Association's Lunar and Planetary Institute (LPI) is seeking applications for one or more full-time staff scientists specializing in planetary science. We are looking for mid-career, self-driven researchers with a proven track record of exceptional research and a history of securing external funding. Early...

  • Hydrogen Research Scientist

    3 weeks ago

    Houston, Texas, United States Aramco Services Company Full time

    Job OverviewPOSITION SUMMARY:The role involves directing and executing investigations that necessitate a robust understanding of industrial laboratory practices or engineering disciplines related to laboratory settings. The incumbent will engage in problem-solving and research studies in chemistry, biology, or other applied sciences pertinent to operational...

  • Senior Research Scientist in Planetary Studies

    4 weeks ago

    Houston, Texas, United States Universities Space Research Association Full time

    Position OverviewThe Universities Space Research Association's Lunar and Planetary Institute (LPI) is seeking applications for one or more full-time staff scientists specializing in planetary science. We are looking for mid-career, self-driven researchers with a proven track record of exceptional scientific contributions and successful external funding...

  • Clinical Research Fellow

    7 days ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Job SummaryHouston Methodist Academic Institute is seeking a highly skilled Clinical Research Fellow to join our team. As a Clinical Research Fellow, you will be responsible for conducting clinical research of a complex nature, planning, executing, and completing clinical research projects under the supervision of a Principal Investigator.Key...

  • Senior Research Scientist in Planetary Studies

    4 weeks ago

    Houston, Texas, United States Universities Space Research Association Full time

    Position OverviewThe Universities Space Research Association's Lunar and Planetary Institute (LPI) is seeking applications for one or more full-time staff scientists specializing in planetary science. We are looking for mid-career, self-driven researchers with a proven track record of exceptional scientific contributions and successful external funding...

  • Neurologist-Scientist - Clinical and Research Opportunities

    2 weeks ago

    Houston, Texas, United States Baylor College of Medicine Full time

    Job SummaryBaylor College of Medicine is seeking a highly qualified Neurologist-Scientist to join our team in Houston, TX. The successful candidate will be appointed at a faculty level commensurate with experience and achievement.Key ResponsibilitiesResearch: Lead a successful basic, translational, and/or clinical research program broadly related to...

  • Postdoctoral Research Scientist

    1 week ago

    Houston, Texas, United States Houston Methodist Full time

    About the RoleWe are seeking a highly motivated and experienced Postdoctoral Fellow to join our team at Houston Methodist Research Institute. The successful candidate will have a strong background in research and a passion for pursuing a novel aspect of the emerging field of Cancer Neuroscience.Key ResponsibilitiesAssist the Principal Investigator in...

  • NASA Johnson Space Center Postdoctoral Research Fellowship

    2 weeks ago

    Houston, Texas, United States Universities Space Research Association Full time

    Position OverviewNASA Johnson Space Center Postdoctoral Research FellowshipThe Astromaterials Research and Exploration Science (ARES) Division at NASA's Johnson Space Center, in collaboration with the Universities Space Research Association's Lunar and Planetary Institute, is excited to announce an opportunity for a distinguished postdoctoral fellowship....

  • Principal Data Scientist

    4 days ago

    Houston, Texas, United States University of Texas MD Anderson Cancer Center Full time

    Job Title: Principal Data ScientistWe are seeking a highly skilled Principal Data Scientist to lead the development and implementation of innovative generative AI models across our organization. As a key member of our team, you will be responsible for developing and deploying AI solutions that drive long-lasting improvements in cancer care.Key...

  • Energy Storage Research Scientist

    4 weeks ago

    Houston, Texas, United States Nabors Industries Full time

    Company Overview Nabors Industries stands at the forefront of technological advancements within the energy sector. Operating across approximately 20 nations, Nabors has built a comprehensive global network that integrates personnel, technology, and equipment to deliver solutions that ensure safe, efficient, and responsible hydrocarbon extraction. By...

  • Hydrogen Research Scientist

    4 weeks ago

    Houston, Texas, United States Aramco Services Company Full time

    Job OverviewPOSITION SUMMARY:The Hydrogen Lab Scientist is responsible for conducting research and investigations that require a deep understanding of industrial laboratory practices and engineering disciplines. This role involves problem-solving and conducting studies in chemistry, biology, and other applied sciences related to operational challenges within...

  • Research Associate in Biomedical Sciences

    3 weeks ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Position Overview: The Research Associate role at Houston Methodist is dedicated to executing fundamental research tasks under the guidance of a Principal Investigator (PI). This position may involve working in a laboratory environment or engaging in computational tasks that bolster the department's research objectives. Key Responsibilities: Assist the...

  • Clinical Research Scholar 2

    4 weeks ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Position Overview: The Clinical Research Scholar role at Houston Methodist involves conducting intricate clinical research projects, guided by a Principal Investigator. This position is designed to offer structured educational experiences and practical applications in areas such as epidemiology, biostatistics, clinical pharmacology, and biomedical...

  • Student Researcher

    2 weeks ago

    Houston, Texas, United States University of Texas M.D. Anderson Cancer Center Full time

    About the RoleWe are seeking a highly motivated and detail-oriented Student Extern to join our team at the University of Texas M.D. Anderson Cancer Center.Key ResponsibilitiesAssist in laboratory research projects focused on the interplay between the immune system, microbes, and tumor behavior.Contribute to the development and implementation of research...

  • Clinical Research Scientist

    4 weeks ago

    Houston, Texas, United States University of Texas M.D. Anderson Cancer Center Full time

    Position Overview:The Research Scientist role is integral to a collaborative research team specializing in genitourinary (GU) medical oncology. This position emphasizes scientific inquiry and innovation in the realm of cancer research.Key Responsibilities:- Engage in multidisciplinary projects focusing on the analysis of pathological images.- Contribute to...

  • Research Scientist

    6 days ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Job SummaryWe are seeking a highly skilled Research Engineer I to join our team at Houston Methodist Academic Institute. This role will provide technical support for laboratory-based research, working under the direction of a Principle Investigator (PI). The successful candidate will be responsible for providing bench techniques, working with laboratory...

  • Laboratory Research Specialist II

    3 weeks ago

    Houston, Texas, United States Houston Methodist Academic Institute Full time

    Position Overview: The Laboratory Research Specialist II role at Houston Methodist involves executing sophisticated laboratory experiments on various research initiatives with limited oversight. Key Responsibilities: Utilizes advanced technical research capabilities to develop and implement testing methodologies and protocols under the guidance of the...

Principal Institute Research Scientist Medicinal Chemistry

4 months ago

Houston, Texas, United States University of Texas MD Anderson Cancer Center Full time

This Institute Principal Research Scientist (Medicinal Chemistry) will lead cross-functional research to discover lead molecules for progression into novel oncology therapeutic agents that benefit patients.

They will be a highly creative synthetic chemist with a strong desire to succeed at the highest level.

They will be responsible for the design, optimization and synthetic execution of small molecule targets from hits to leads, as well as leadership/management of junior scientists and project teams towards those goals.

By liaising with other members of the cross-functional project team, this individual will play a key role in the identification and optimization of the next generation of cancer therapeutics.


JOB SPECIFIC
COMPETENCIES
Know your business

  • Apply and develop cutting-edge medicinal chemistry tools and methodologies to enable advancement of Institute projects through leadership and experimental activities.
  • Analyze data generated by various studies and leverage results for the design of future target molecules.
  • Collaborate with data scientists to triage high-throughput screening results and identify promising hits using cheminformatics techniques (e.g. clustering, physicochemical property prediction)
  • Apply chemistry-based data analytics software to identify early-SAR trends, track series progressibility, and design/optimize focused libraries
  • Apply state of the art chemistry skills to optimize molecules from diverse hit-finding exercises to enable progression of programs into lead optimization. Leverage latest synthetic approaches, parallel medicinal chemistry and purification techniques.
  • Adapt to new technologies and find solutions to related program studies.
  • Lead in the design and synthesis of small molecule modulators of protein targets through lab-based activities.
  • Lead in the hypothesis generation and design of new target molecules with improved overall profile.
  • Work closely with medicinal chemists, computational chemists and other project team members in the design and optimization of compounds with improved potency, selectivity, and functional activity on their protein target, together with improved ADME properties.
  • Trouble shoot synthetic issues with their synthetic targets, as well as those of other project team members.
  • Manage patent filings in order to secure the intellectual property rights for novel small molecules.
  • Employ safe lab practices.
  • Maintain research records and laboratory notes.
Know the business of your department/institute

  • Interact across functions.
  • Employ safe lab practices.
  • Maintain research records and laboratory notes.
  • Self-adaptability: Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.
Change Agent

  • Adapt to new technologies and find solutions to related program studies.
Other duties as assigned

COMPETENCIES
Analytical Thinking - Gather relevant information systematically; break down problems into simple components; make sound decisions.

Innovative Thinking - Approach problems with curiosity and open-mindedness; offer new ideas, solutions and/or options.


Self-Adaptability - Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.

Self-Confidence - Recognize own knowledge, skills, and abilities; respond to challenging situations with confidence; understand limits in self.


Team with Others - Initiate, develop, and manage relationships and networks; encourage collaboration and input from all team members; value the contributions of all team members; balance individual and team goals.


Technical/Functional Expertise - Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.

Service Orientation

Provide service to our customers, including patients, patient caregivers, referring physicians and each other, in a reliable, responsive, safe, friendly and courteous manner.


  • Promote inclusiveness and collegiality by demonstrating respect and professionalism to others at all times.
  • Model safe, ethical behavior, mitigating risk to the institution through sound business practices, and adherence to MD Anderson's Standards of Conduct, institutional policies and procedures.
  • Meet time and attendance expectations and responds to requests in a timely manner, communicating expectations for procedures, service arrival, or project deliverables to patients and coworkers.
  • Admit when wrong, apologize and take steps to resolve a situation to help patients and coworkers before being asked.

Onsite Presence:
Is Required

WORKING CONDITIONS
Frequency

Hazardous Chemicals and Materials

Frequent 34-66%

PHYSICAL DEMANDS
Frequency

Weight

Standing
Walking
Sitting
Reaching
Lifting
Pushing/Pulling
Keyboarding

Frequent 34-66%
Occasionally 11-33%
Constant 67-100%
Occasionally 11-33%
Occasionally 11-33%
Occasionally 11-33%
Frequent 34-66%

5-10 lbs
5-10 lbs

EDUCATION:


Required:
PhD in one of the natural sciences or related field or Medical degree.

EXPERIENCE:


Required:
Five years experience of relevant research experience in lab.

Preferred:

The ideal candidate will have a PhD in Organic Chemistry, postdoctoral experience in organic synthesis and 10-15 years of experience working in biopharma company medicinal chemistry labs.

Strong knowledge of contemporary synthetic organic chemistry, with a demonstrated track record of creative independent problem-solving.

Strong familiarity with the latest hit-finding techniques, included DNA-encoded libraries, fragment screening and affinity-selection mass spectrometry methods, with demonstrated success moving hits into lead optimization.

Skilled experimentalist with demonstrated ability to conduct challenging multi-step organic chemistry synthesis and overcome synthetic hurdles, trained in various purification and analytical techniques.

Strong publication record in peer reviewed journals. Familiarity with automated and computational chemistry, including datamining software.

Experience mentoring and managing chemists and leading hit-to-lead exercises, as well as knowledge of the drug discovery process, is required.

Excellent oral and written communication skills and organizational skills are a must.

Familiarity with relevant biological disciplines and ability to integrate knowledge from these areas into the design of new bioactive compounds.


It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.