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Institute Research Scientist Cell Biology

2 months ago


Houston, Texas, United States MD Anderson Cancer Center Full time
Job Title: Research Scientist Cell Biology

We are seeking a highly motivated and talented Research Scientist to join our Reverse Translation group at the MD Anderson Cancer Center. As a key team member, you will be responsible for developing and independently leading research activities to advance projects from target validation through preclinical development to clinical proof-of-concept studies.

Key Responsibilities:
  • Independently lead and manage target and translational biology research activities on multiple discovery projects, delivering compelling validation packages and translational data to advance programs into clinical proof-of-concept trials in defined patient populations.
  • Design, execute, analyze, and interpret in vitro, ex vivo, and in vivo experiments to validate novel therapeutic targets, inform on target mechanism of action, and explore translational hypotheses.
  • Work closely with the data science team to present and interpret research findings to refine the experimental strategy.
  • Deploy cutting-edge tools and technologies to develop in vitro and in vivo advanced cancer modeling, creation of somatic GEMM models, engineering of drug resistance mechanisms, and unprecedented oncogenic drivers.
  • Propose and lead innovative solutions to advance research projects.
  • Deploy functional genomics to enable novel target identification and deep functional characterization of relevant tumor contexts.
  • Deploy cutting-edge epigenomic assays to evaluate mechanisms of therapy resistance and tumor evolution.
  • Proactively identify, evaluate, and implement novel technologies to drive research discoveries and innovation.
  • Apply knowledge of pharmacology and biomarker development to enable in vivo assessment of chemical matter and establish pharmacokinetic, pharmacodynamic, and efficacy relationships.
  • Contribute to project team through lab-based activities.
  • Develop strong collaborative relationships with internal and external groups.
  • Interpret, present, and report research findings at internal meetings and external scientific conferences.
  • Manage dedicated associate scientists towards project objectives.
Requirements:
  • Master's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry, or related field.
  • PhD, MD, or equivalent degree in biology, cell biology, pharmacology, or related field preferred.
  • Six years of relevant research experience in laboratory, with a PhD in a natural science or medical degree, two years of required experience, or with a Bachelor's, ten years of relevant research experience in laboratory.
  • Relevant research and management experience beyond post-doctoral research maintaining hands-on experience, industry R&D experience preferred.
About Us:

The MD Anderson Cancer Center is a world-renowned institution dedicated to advancing cancer research and treatment. Our Therapeutics Discovery Division is a multidisciplinary team of researchers, doctors, and scientists working together to develop innovative therapies for cancer patients. As a Research Scientist, you will be part of a dynamic team that is pushing the boundaries of cancer research and treatment.

We are committed to providing a collaborative and inclusive work environment that fosters innovation and excellence. If you are a motivated and talented researcher looking to make a difference in the fight against cancer, we encourage you to apply for this exciting opportunity.