Senior Principal Scientist, Global Discovery Chemistry,

1 month ago

House Springs, Missouri, United States Johnson & Johnson Full time
At Johnson & Johnson,we believe health is everything.

Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at


The Peptide group within Global Discovery Chemistry group is committed to the delivery of high-quality drug candidates working across all Therapeutic Areas (TAs).

This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.

Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as Scientist, Discovery Chemistry.

This position will be based at our drug discovery site in Spring House, PA.

We are seeking an experienced, highly skilled, and motivated chemist with excellent peptide chemistry and medicinal chemistry expertise to shepherd peptide drug discovery programs and advance them toward the clinic.

This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy.

Using a mix of internal and external resources, the Principal Scientist will partner with key stakeholders in the TAs and other internal groups, represent medicinal chemistry, lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules.


Responsibilities of the Senior Principal Scientist will include:

  • Independently designing and synthesizing drug-like peptide molecules utilizing current medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.
  • Drive Medicinal Chemistry, Peptide programs for one or more drug discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and contract research organizations (CROs)
  • Apply and build Peptide capabilities using state-of-the-art design, chemistry, and technology across Therapeutic Discovery
  • Excellent communication to develop effective partnerships across J&J and with external partners
  • Contribute to portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement
  • Serve as a scientific expert in peptide and medicinal chemistry with both internal and external partners and provide recommendations regarding emerging opportunities.
  • Analyze synthetic routes to designed compounds, screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies
  • Provide scientific direction and leadership for synthetic and medicinal chemistry activities of internal, external FTEs and contract research organizations (CROs). This role may have direct people management responsibilities.
  • Participate in shaping and implementing strategies that support synthetic and medicinal chemistry growth objectives at J&J, including academic relations and talent acquisition
  • Ensure optimal interaction/communication and provide updates on project status to leadership
  • Maintain a significant level of productivity in the laboratory setting
Qualifications

  • PhD in peptide, synthetic organic, or medicinal chemistry or relevant industrial experience (>7 yr)
  • A minimum of 5 or more years' additional experience in the biopharmaceutical industry working with Peptides.
  • Experience designing peptides using computational modeling tools including (1) peptide conformational restraints to influence secondary structure, (2) constrained macrocycles for affinity or properties, and/or (3) de-peptidization strategies including back-bone modifications and peptidomimetics
  • Good understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology,
pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates

  • Knowledge of and/or experience with computational chemistry methods and biophysical techniques such as X-ray crystallography and macromolecular NMR
  • Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives
  • Demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed within a matrixed, global environment

Preferred:

Experience is:
o Permeable and orally bioavailable peptides

o Peptide hit finding approaches

o Intracellular protein-protein interaction targets

o Cell penetrating peptides

o Chemical biology using cyclic peptide scaffolds

  • Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings
  • Oral peptide design strategies, including half-life extension approaches and incorporation of unnatural amino acids is preferred
  • Demonstrated operational skills for contributing to discovery programs at the level of a senior chemist
  • Broad experience and proven accomplishments in one or more Therapeutic Areas

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