Biophysics Scientist

2 months ago

San Francisco, California, United States Nurix Therapeutics Full time

Position

We are seeking a talented scientist with a strong background in Biophysics to join our Drug Discovery Technology Department. In this laboratory-based position (one year contract with an opportunity to renew), you will be part of a diverse team that is focused on advancing projects by collecting and interpreting biophysical assay data for ongoing discovery programs, hit identification, and hit to lead efforts. You also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to project teams and senior management. The successful candidate will have the opportunity to directly contribute in the following areas:

Plan and execute small molecule-protein biophysical assays to characterize binding affinity and kineticsIdentify novel chemical matter using biophysical screening techniques of extensive small molecule compound librariesCharacterize the binding affinity and kinetics of binary and tertiary complexes of proteins and targeted protein degrader moleculesCharacterize the binding of small molecule-DNA conjugate molecules from DNA-encoded library (DEL) screening campaignsEvaluate new technologies and develop novel biophysical assaysEngage in cross-functional team discussions that support our DEL screening groups, internal project teams, collaboration projects, and machine learning effortsPrepare reports and present data at internal group meetings

Education and ExperiencePh.D. in Biophysics, Biochemistry, or related discipline with up to 3 years relevant experience OR MS with 5 years relevant experience, OR BS or equivalent with 10 years relevant experienceExperience using biophysical techniques to analyze protein-small molecule interactionsExtensive, hands-on laboratory experience in the use of Surface Plasmon Resonance biosensors (SPR) or Grating-Coupled Interferometers (GCI)Expertise in the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysisPractical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferredExcellent communication skills and ability to present scientific rationale, key data, issues and accomplishments to other scientific colleagues

Added QuantificationsExperience working in PROTAC-based drug discovery programsExperience working with molecular biology tools (PCR, qPCR, Western Blot)Experience with medicinal chemistryGood fit with Nurix culture

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