Scientist II – Process Development

1 month ago

New York, New York, United States BlueRock Therapeutics Full time

BlueRock Therapeutics is seeking a Scientist, Process Development based in our New York City, New York location. As a central development resource at the company, the Process Development team works with Research, Non-clinical, Analytical Development, GMP operations including Manufacturing, and Quality teams. As a key contributor within this function, the incumbent will help lead the optimization and scale up efforts of a closed and automated 3D platform for expansion of pluripotent stem cells. This is an outstanding opportunity for a talented and self-motivated scientist to gain valuable career experience in Process Development. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients' lives. The role will be a predominantly lab based.

Responsibilities:

  • Design, execute, oversee, and interpret experiments in partnership with other team members.
  • Independently draft, review, and finalize both technical protocols and scientific reports while interacting in a cross- specialty environment.
  • Help determine process parameters range for cell culture and downstream processing to optimize PSC starting material yield and quality in a bioreactor system.
  • Identify important process parameters and implement appropriate analytics.
  • Maintain and culture PSCs utilized as starting material for downstream differentiation. This includes regular weekend/holiday in-lab activities.
  • Assess gaps in PSC maintenance and growth conditions for banking, including platform evaluation, GMP-readiness and scale up efforts.
  • Collaborate, cross-functionally, to solve scientific problems outside of function.
  • Coordinate with platform and research teams as well as other Tech Ops groups to prioritize and plan characterization and distribution of cell materials.
  • Participate in tech transfer activities to Manufacturing.
  • Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner.
  • Prepare and follow standard operating procedures, batch records, reports, and other process documentation.
  • Mentor and motivate others in scientific and/or technical topics with the goal of enabling key activities to be completed appropriately and on-time.
  • Organize and present scientific data to peers at internal platforms.

Minimum Requirements:

  • Ph.D or MSc. degree in a Biological Science, such as Biochemistry, Immunology, Molecular Biology, or similar
  • Ph.D 2+ years of experience or MSc. 10+ years of experience, preferably in an industry setting
  • Extensive mammalian cell culture and cell characterization experience, ideally with PSCs
  • Practical knowledge of experimental design (e.g., DoE) software and statistical analysis of data
  • Understanding and experience of molecular techniques such as cell imaging, flow cytometry, or qPCR and ddPCR is desired.
  • Ideally experience with Bioreactor cell culture and bioprocessing.
  • Ability to plan experiments and independently execute complex tasks.
  • Strong English written and verbal communications skills.
  • Proficiency in technical scientific writing.
  • Ability to work in a fast-changing environment.
  • Collaborative team player

#LI-AL1

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