Current jobs related to (Senior) Scientist, Lead Discovery - San Francisco - Site Therapeutics
-
Senior Scientist
3 weeks ago
San Diego, California, United States Antharis Therapeutics, Inc. Full timeJob Title: Senior/Principal ScientistWe are seeking a highly motivated and experienced Senior/Principal Scientist to join our team at Antharis Therapeutics, Inc. in San Diego. As a key member of our pre-clinical team, you will be responsible for leading antibody discovery and development programs.Key Responsibilities:Propose and carry out research on novel...
-
Senior Scientist, Discovery Biology
1 month ago
South San Francisco, California, United States Biogen Full timeJob Title: Senior Scientist, Discovery BiologyWe are seeking a highly motivated Senior Scientist with a background in discovery biology to drive the discovery and validation of novel therapeutic targets in autoimmune and inflammatory diseases.Key Responsibilities:Establish novel workflows for generating RNA-seq datasets and cell-based assay development for...
-
Scientist Antibody Discovery
4 weeks ago
South San Francisco, United States Global Channel Management, Inc Full timeScientist Antibody Discovery needs significant experience in antibody discovery and protein engineering by using single B cell cloning hybridoma or phage/yeast display techniques Scientist Antibody Discovery requires: PhD in Biochemistry Biomedical/Chemical Engineering Immunology or related field with minimum of 2 years of postgraduate experience...
-
Scientist Antibody Discovery
2 months ago
South San Francisco, United States Global Channel Management, Inc Full timeScientist Antibody Discovery needs significant experience in antibody discovery and protein engineering by using single B cell cloning hybridoma or phage/yeast display techniques Scientist Antibody Discovery requires: PhD in Biochemistry Biomedical/Chemical Engineering Immunology or related field with minimum of 2 years of postgraduate experience...
-
Senior/Principal Scientist
4 weeks ago
San Diego, California, United States Antharis Therapeutics, Inc. Full timeJob Title: Senior/Principal ScientistAt Antharis Therapeutics, Inc., we are seeking a highly motivated and experienced Senior/Principal Scientist to join our team in San Diego. As a key member of our research team, you will be responsible for leading the discovery and development of novel immunotherapeutics, including monoclonal antibodies and antibody-drug...
-
Antibody Discovery Scientist
2 weeks ago
South San Francisco, California, United States Global Channel Management, Inc Full timeJob Title: Scientist Antibody DiscoveryGlobal Channel Management, Inc is seeking a highly skilled Scientist Antibody Discovery to join our team. The ideal candidate will have significant experience in antibody discovery and protein engineering using single B cell cloning hybridoma or phage/yeast display techniques.Key Responsibilities:Design and execute...
-
Antibody Discovery Scientist
2 weeks ago
South San Francisco, California, United States Net2Source Inc. Full timeJob Title: Scientist, Antibody DiscoveryWe are seeking a highly motivated and experienced Scientist, Antibody Discovery to join our growing team at Net2Source Inc.Job Summary:The successful candidate will be responsible for designing and executing antibody discovery campaigns for therapeutic and reagent antibodies using phage display. This includes...
-
Senior Antibody Discovery Scientist
2 weeks ago
South San Francisco, California, United States Joulé Full timeJob Opportunity: We are seeking a highly motivated and experienced Antibody Discovery Scientist to join our team at Joulé. As a key member of our biologics development team, you will be responsible for designing and executing antibody discovery campaigns for therapeutic and reagent antibodies using phage display. Responsibilities: • Design strategies and...
-
Antibody Discovery Scientist
1 month ago
South San Francisco, California, United States Net2Source Inc. Full timeJob Title: Scientist, Antibody DiscoveryWe are seeking a highly motivated and experienced Scientist, Antibody Discovery to join our growing team at Net2Source Inc. in South San Francisco, CA.Job Summary:The successful candidate will design and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display, generate antibody...
-
Scientist Antibody Discovery Specialist
4 weeks ago
South San Francisco, California, United States Global Channel Management, Inc Full timeScientist Antibody Discovery Job DescriptionWe are seeking a highly motivated and experienced Scientist Antibody Discovery to join our team at Global Channel Management, Inc.Key Responsibilities:Design and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage displayGenerate antibody fragment libraries for antibody discovery...
-
Scientist NMR Spectroscopy Lead Discovery
1 month ago
South San Francisco, United States Amgen Full timeHOW MIGHT YOU DEFY IMAGINATION?Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology...
-
Senior Research Scientist, Biomarker Discovery
2 months ago
San Diego, California, United States Neurocrine Biosciences Full timeAbout the RoleWe are seeking a highly skilled Senior Scientist to join our team at Neurocrine Biosciences. As a Senior Scientist, you will be responsible for developing and validating biomarker assays to support our drug development pipeline.Key ResponsibilitiesDesign, develop, and perform robust clinical biomarker assaysIdentify and evaluate new...
-
Principal Scientist, Discovery Immunology
2 weeks ago
South San Francisco, California, United States Parvus Therapeutics Full timeJob Title: Principal Scientist, Discovery ImmunologyParvus Therapeutics Inc. is a biopharmaceutical company developing innovative treatments for autoimmune diseases. We are seeking a Principal Scientist to join our Discovery Immunology Team and contribute to the development of our Navacims platform.Key Responsibilities:Lead the identification and selection...
-
Senior Scientist, Early Discovery Program
1 week ago
San Diego, California, United States Light Horse Therapeutics Full timeJob Opportunity at Light Horse TherapeuticsWe are seeking a highly motivated and experienced Principal Scientist to join our Discovery Biology group at Light Horse Therapeutics. As a key member of our team, you will contribute to the development of innovative small molecule discovery approaches for high-value oncology targets.Key Responsibilities:Design and...
-
Senior Scientist, Translational Medicine Expert
1 month ago
San Francisco, California, United States Genentech Full timeJob OpportunityWe are seeking a highly skilled Senior/Principal Scientist to lead lab-based translational research and discovery efforts in the clinical proteomics and mass spectrometry laboratory at Genentech.Key ResponsibilitiesDesign and execute mass spectrometry/clinical proteomics experiments to explore novel biomarker hypotheses and collaborate with...
-
Senior Bioconjugation Scientist
2 weeks ago
South San Francisco, California, United States Global Channel Management Full timeBioconjugation Large Molecule Discovery RoleWe are seeking a highly skilled Senior Bioconjugation Scientist to join our team at Global Channel Management.Key Responsibilities:Design and execute experiments to develop and optimize bioconjugates using various conjugation chemistries.Collaborate with cross-functional teams to develop and implement ADC...
-
San Francisco, California, United States Net2Source Inc. Full timeWe are seeking a highly motivated and experienced Scientist Consultant, Antibody Discovery to join our growing team at Net2Source Inc.Job Summary:The ideal candidate will have a strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins.Key Responsibilities:Design...
-
Senior Product Manager
1 week ago
San Francisco, California, United States WEX Full timeAbout the Role:As a Senior Product Manager on WEX Inc.'s Innovation & Discovery team, you will rapidly identify customer problems and validate product market fit for solutions that transform the day-to-day operations for our B2B target customers. In this role, you will collaborate closely with design and engineering on a small, agile discovery team focused...
-
Senior Scientist, Translational Medicine Expert
4 weeks ago
San Francisco, California, United States Genentech Full timeThe OpportunityWe are seeking a highly skilled Senior/Principal Scientist to lead lab-based translational research and discovery efforts in the clinical proteomics and mass spectrometry laboratory at Genentech.This is a hands-on, lab-based position that requires close collaboration with colleagues and departments across multiple functions in Genentech...
-
San Diego, United States Light Horse Therapeutics Full timeLight Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...
(Senior) Scientist, Lead Discovery
3 months ago
Site Therapeutics aims to map—down to the nucleotide—the genetic determinants driving immune cell function in human health and disease and to use that information to develop first-in-class small molecule therapeutics for autoimmune disease. Leveraging technology developed in the Marson Lab at UCSF/Gladstone, we will conduct high-throughput functional genomics in human cells to build a blueprint for fine-tuned control of immune cell function. This detailed map will lead to the development of new therapeutics across modalities for a range of immune-related conditions. We are backed by The Column Group, a leading life sciences venture capital firm.
We are seeking a highly motivated and innovative biochemist and small molecule discovery scientist to join our growing Lead Discovery group at Site Tx. The Lead Discovery group drives the translation of novel functional sites on proteins, identified by our base editing platform, into small molecule effectors that phenocopy these functional effects and enable the development of small molecule therapeutics. In this role, you will provide expertise in devising and developing the functional assays and screening methodologies that will identify these molecules and characterize them biophysically and structurally to enable progression through structure-based drug design campaigns. This role represents an opportunity to join a company at the earliest stages and have an outsized impact in its growth and success.
Primary Responsibilities
- Using biophysics, biochemistry, and structural biology to characterize and elucidate the function of novel protein target sites identified by Site Tx’s base-editing functional genomics platform
- Operationalizing and conducting small molecule discovery on these target sites by various approaches, including biochemical high-throughput screening and DNA-encoded library (DEL) selection
- Characterizing hit compound mechanisms of action through biochemical, biophysical, and structural characterization
- Progressing these small molecules toward the clinic through structure-based drug design campaigns as a member of a cross-functional team consisting of medicinal chemists, computational chemists, cell biologists, and pharmacologists
- Presentation of research findings to senior management and other stakeholders, both within and outside the company
Qualifications:
- Ph.D. in biochemistry, biophysics, structural biology or related fields with 2+ years post degree experience
- Demonstrated success using screening methodologies and SBDD to identify, characterize, and progress small molecules against novel therapeutic targets
- Experience using protein science to develop high quality, functional protein reagents for downstream assay development and discovery (multiple expression systems, protein purification, QC, optimization)
- Experience developing fluorescence-based activity and protein interaction assays (TR-FRET, FP, etc.) for the characterization of protein-protein and protein-small molecule interactions
- Experience developing biophysical protein interaction systems (SPR, GCI)
- Strong track record of scientific accomplishment (publications, presentations, industry experience)
- Strong desire to operate and thrive in a fast-paced, collaborative, and exciting scientific environment translating novel biological insights into transformative therapeutics for patients
We offer:
In addition to a competitive compensation package with stock options, we offer comprehensive health, dental, and vision benefits for employees and their families.
We believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.
Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.
