Senior Scientist, Early Discovery Program

4 weeks ago


San Diego, California, United States Light Horse Therapeutics Full time
Job Opportunity at Light Horse Therapeutics

We are seeking a highly motivated and experienced Principal Scientist to join our Discovery Biology group at Light Horse Therapeutics. As a key member of our team, you will contribute to the development of innovative small molecule discovery approaches for high-value oncology targets.

Key Responsibilities:
  • Design and implement early discovery strategies for challenging oncology targets, leveraging techniques from multiple disciplines.
  • Develop and execute screening funnels using cellular and/or biochemical assays to discover small molecule inhibitors.
  • Contribute to target selection and validation for the early discovery pipeline.
  • Communicate science and strategy effectively in internal meetings and prepare written reports of data and literature analyses.
  • Manage team members to accelerate discovery across multiple programs.
Requirements:
  • PhD in Chemical Biology, Molecular/Cell Biology, Biochemistry/Enzymology, or a related field with 6+ years of biopharmaceutical industry research experience.
  • Experience implementing small molecule screening and drug discovery strategies in early and/or hit-to-lead discovery programs.
  • Strong experience in mechanistic target biology research and familiarity with a multitude of drug discovery strategies.
  • Prior experience managing direct reports and demonstrated ability to multi-task, prioritize options, and accomplish goals in a fast-paced research environment.
What We Offer:

We offer a competitive total compensation package and a supportive team environment. The anticipated salary range for candidates who will work in San Diego, CA is $150,000 to $210,000, dependent on several factors including experience, education, and qualifications.



  • South San Francisco, California, United States Joulé Full time

    Job Opportunity: We are seeking a highly motivated and experienced Antibody Discovery Scientist to join our team at Joulé. As a key member of our biologics development team, you will be responsible for designing and executing antibody discovery campaigns for therapeutic and reagent antibodies using phage display. Responsibilities: • Design strategies and...


  • San Diego, California, United States Pfizer Full time

    Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Tumor Immunity team focused on delivering breakthroughs that change patients' lives by redirecting the immune system against cancer.The Senior Principal Scientist will be responsible for driving scientific strategies and their...


  • San Diego, California, United States Discovery Isle Preschool Full time

    Job SummaryWe are seeking a highly skilled and passionate Infant Toddler Teacher to join our team at Discovery Isle Preschool. As a key member of our early childhood education team, you will be responsible for creating a nurturing and engaging learning environment for our youngest students.Key Responsibilities:Implement our proprietary curriculum, ensuring a...


  • San Diego, California, United States Amazon Full time

    About the RoleAs a Senior Data Scientist at Amazon, you will be part of the Minerva team, a cross-functional science, analytics, and ML org of highly experienced scientists, BI/data engineers, and software engineers. We build science-based systems for marketing and content-discovery for indie authors, fraud/abuse, and content risk for our publishing...


  • San Diego, California, United States Discovery Isle Preschool Full time

    Preschool Teacher OpportunityDiscovery Isle Preschool is seeking a qualified Preschool Teacher to join our team. As a Preschool Teacher, you will be responsible for coordinating classroom operations and implementing our proprietary literacy-based curriculum. Our curriculum is designed to be flexible and adaptable to meet the unique needs of each student.Key...


  • San Diego, California, United States WuXi AppTec Full time

    Job SummaryWuXi AppTec is seeking a highly motivated and established scientist with deep expertise in in vitro biology and cell science to join our team. The successful candidate will lead a team in San Diego to provide scientific services and solutions to our customers' drug discovery research needs.Responsibilities• Manage and lead in vitro scientific...


  • San Diego, California, United States Poseida Therapeutics, Inc. Full time

    Job SummaryPoseida Therapeutics, Inc. is seeking a highly motivated Research Scientist to join our Gene Therapy team in San Diego, CA. This position offers an exciting opportunity to discover and develop next-generation products using Poseida's best-in-class genome editing, gene insertion, and delivery technologies.Key ResponsibilitiesManage and execute in...

  • Senior Data Scientist

    3 weeks ago


    San Diego, California, United States Intuit Full time

    Senior Data ScientistIntuit is seeking a highly skilled Senior Data Scientist to join our AI team. This team embeds artificial intelligence and machine learning into our product portfolio and business to create smarter products, improve anti-fraud and security, and enhance customer care.This role involves building and deploying machine learning models using...


  • San Diego, California, United States WuXi AppTec Full time

    Job Summary:WuXi AppTec is seeking a highly motivated and established scientist with deep expertise in in vitro biology and cell science to join our team. The successful candidate will lead a team in San Diego to provide scientific services and solutions to our customers' drug discovery research needs.Responsibilities:• Manage and lead in vitro scientific...


  • South San Francisco, California, United States Parvus Therapeutics Full time

    Job Title: Principal Scientist, Discovery ImmunologyParvus Therapeutics Inc. is a biopharmaceutical company developing innovative treatments for autoimmune diseases. We are seeking a Principal Scientist to join our Discovery Immunology Team and contribute to the development of our Navacims platform.Key Responsibilities:Lead the identification and selection...


  • San Mateo, California, United States Roblox Full time

    Join Our Team as a Senior Product Manager for Marketplace DiscoveryAt Roblox, we're building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device.We're looking for a Senior Product Manager to lead the...


  • San Diego, California, United States RESILIENCE Full time

    Join Our Team at ResilienceWe're a technology-focused biomanufacturing company that's changing the way medicine is made. Our mission is to build a sustainable network of high-tech, end-to-end manufacturing solutions to better withstand disruptive events, serve scientific discovery, and reach those in need.As a Senior Research Scientist - Biology, you will...


  • San Diego, California, United States Antharis Therapeutics, Inc. Full time

    We are seeking a highly motivated and experienced antibody discovery/development scientist to join our team at Antharis Therapeutics, Inc. The ideal candidate will have a strong background in immunology, biochemistry, or a related field, with 5+ years of post-doc or corporate experience in antibody discovery and development.Key Responsibilities:Propose and...


  • San Diego, California, United States Web-atrio Full time

    Job SummaryWe are seeking a highly skilled Machine Learning Scientist to join our Predictive Sciences team. As a Senior Principal Scientist, you will be responsible for developing and implementing innovative machine learning approaches to improve small-molecule design and prediction. Your expertise in deep learning methods, particularly in active learning,...


  • San Marcos, California, United States Discovery Isle Preschool Full time

    Early Childhood Education OpportunityDiscovery Isle Preschool is seeking a dedicated and passionate Preschool Teacher to join our team. As a Preschool Teacher, you will play a vital role in creating a nurturing and engaging learning environment for our young students. **Key Responsibilities:**• Coordinate classroom operations, including the implementation...


  • San Diego, California, United States Illumina Full time

    At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than...

  • Senior Scientist I

    4 weeks ago


    San Diego, California, United States ADARx Pharmaceuticals Inc. Full time

    Job DescriptionWe are seeking a highly motivated and experienced Senior Scientist I to join our Discovery Chemistry Department at ADARx Pharmaceuticals Inc. The ideal candidate will have a strong background in bioconjugation chemistry and a proven track record of driving projects to key decision points.Key Responsibilities:Perform bioconjugation,...


  • San Diego, California, United States Department of Parks & Recreation Full time

    Job Description and DutiesThe Department of Parks & Recreation is seeking a highly skilled Senior Environmental Scientist to join our team. As a key member of our Resources Program, you will work under the general direction of the Senior Environmental Scientist (Supervisory) to coordinate legislatively mandated resource management plans and...


  • San Diego, California, United States Neurocrine Biosciences Full time

    About the Role:We are seeking a highly skilled Senior Scientist to join our team at Neurocrine Biosciences. As a Senior Scientist, you will be responsible for developing and validating biomarker assays to help confirm drug target engagement, understand mechanisms of action and patient response.Your Key Responsibilities:Design, develop, and perform robust...


  • San Mateo, California, United States Net2source Full time

    Job Title: Associate Scientist - Biology Immuno-oncologyWe are seeking a highly motivated and talented Associate Scientist to join our Immuno-oncology group at Net2source. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic.The successful candidate will...