Antibody Discovery Scientist

3 days ago


South San Francisco, California, United States Global Channel Management, Inc Full time
Job Title: Scientist Antibody Discovery

Global Channel Management, Inc is seeking a highly skilled Scientist Antibody Discovery to join our team. The ideal candidate will have significant experience in antibody discovery and protein engineering using single B cell cloning hybridoma or phage/yeast display techniques.

Key Responsibilities:
  • Design and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display
  • Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multiplex flow cytometry) and sequence analysis to generate hits
  • Rank and order clones by affinity, in vitro potency, and early developability assessment
  • Execute sequence optimization of lead antibodies to improve developability and binding affinity
Requirements:
  • PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with a minimum of 2 years of postgraduate experience (preferably in industry)
  • MS with 8 years of research experience or BS with 10 years of research experience in antibody or protein engineering
  • Strong background in molecular biology, antibody, and protein expression, and biophysical characterization of recombinant antibodies and proteins
  • Demonstrated experience in working collaboratively across various scientific disciplines and other parts of the organization to meet end goals
  • Highly motivated individual with exceptionally good organizational skills and attention to details
  • Experience in single domain antibodies, multispecific antibody engineering, Fc engineering, antibody drug conjugates, nave phage or yeast display library design, and NGS analysis for antibody discovery and engineering
  • Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry
Work Environment:

No remote work is available for this position.



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