Principal Scientist

1 month ago

Cambridge MA United States Delphia Therapeutics Full time

Principal Scientist / Associate Director, In vivo Pharmacology

About Us:

Delphia is a biotechnology company on a mission in the service of patients to pioneer an entirely new field of cancer biology, Activation Lethality, that targets cancer’s vulnerability to oncogene overactivation. Together, we are working to advance first-in-class targeted cancer medicines that can provide better and more durable outcomes for patients, particularly where drug resistance is observed. Partnering together in a supportive, open, and collaborative environment, we share a sense of purpose, urgency and commitment to patients to approach cancer biology through a different perspective and to establish Activation Lethality as the next wave of oncology therapeutics.

The Difference You’ll Make

  • Delphia is searching for a Principal Scientist /Associate Director, In vivo Pharmacology to join the team The In vivo pharmacologist will be responsible for the development and execution of the in vivo strategy to advance a growing pipeline of first-in-class targeted cancer medicines designed to provide better outcomes for patients. The candidate will collaborate closely with the chemistry, biology, toxicology, DMPK, translational and future clinical development teams in leading our efforts designed to address key questions related to how our molecules behave in vivo.

What You’ll Do:

  • Provide in vivo pharmacology expertise to lead the design and implementation of the in vivo pharmacology strategy across Delphia’s discovery portfolio.
  • Serve as the in vivo pharmacology lead on project teams providing clear strategic direction as well as organize, maintain, and present research data at the project team level.
  • Work collaboratively with the biology, chemistry, and DMPK groups to develop an in vivo study plan for establishing PK/PD/efficacy for early molecule development as well as exploratory studies designed to understand how to leverage the novel activation lethality mechanism of action.
  • Plan, analyze and interpret in vivo efficacy studies in collaboration with a contract research organization in order to support program goals and objectives.
  • Prepare regulatory submission documentation, author in vivo pharmacology sections of regulatory documents.
  • Identify and manage consultants and vendors for additional in vivo pharmacology support as necessary.

What you bring:

  • PhD in a biology with 5+ years of experience in biotech/pharmaceutical industry.
  • Expertise and a broad understanding the design, execution and analysis of in vivo studies with small molecule oncology drugs.
  • Extensive knowledge of basic biology, PK, toxicology, and clinical study design.
  • Demonstrate innovative thinking driving towards cutting-edge approaches.
  • Proactive at solving complex problems within a collaborative, fast-paced, matrixed team environment.
  • Experience and proficiency in managing activities at CROs and preparing data packages for regulatory submission.
  • Experience leading in vivo pharmacology efforts for early-stage discovery projects and familiarity with the drug discovery and development process.
  • Ability to operate objectively and independently as a leader and as a member of a team.
  • Excellent verbal and written communication skills necessary for effective collaboration and presentation of data.
  • Comfort operating in complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors, and internal cross-functional teams.

  • Principal Scientist, MAPS

    4 days ago

    Cambridge, MA, United States GlaxoSmithKline Full time

    Site Name: USA - Massachusetts - CambridgePosted Date: Dec 4 2024The Principal Scientist, MAPS will be a part of the Process Development group under Technical R&D. The Principal Scientist is expected to design and execute scientific studies in support of technical programs as they progress from early development into Phase I/ II, Phase III, technology...

  • Principal Scientist, Analytical Development

    5 days ago

    Cambridge, MA, United States Apex Systems Full time

    Principal Scientist, Analytical Development Location : Cambridge, MA (Onsite)Science: Small Molecule Therapeutics Job Overview: The Principal Scientist in Analytical Development guides pharmaceutical advancements from inception through clinical stages and collaborates with internal and external partners. Primary Job Responsibilities: Develop specialized...

  • Principal Scientist

    4 days ago

    Woburn, MA, United States Spear Bio Inc. Full time

    Spear Bio is a well-funded and rapidly growing start-up company based in Woburn, Massachusetts. We are focused on bringing to market a novel ultrasensitive immunoassay platform utilizing very small sample volumes. The commercial focus of the company is dedicated to supporting life sciences, clinical, and academic research. Our platform offers best-in-class...

  • Principal Cheminformatics Scientist

    4 days ago

    Cambridge, MA, United States Newton Colmore Consulting Full time

    Principal Cheminformatics Scientist - Drug Discovery Newton Colmore is working for a start-up drug discovery biotech and we are assisting them in their search for a cheminformatics expert to join their research team. The company is seeking an experienced Cheminformatics Scientist to join their multidisciplinary team in Boston, MA and help run their...

  • Principal Health Scientist

    5 days ago

    Newton, MA, United States Energy Jobline AZ Full time

    Principal Scientist Summary: Principal Scientists direct or manage projects with potentially high stakes, requiring thoughtful application of the appropriate technical disciplines and professional judgment. They oversee the scope and quality of service delivery from the beginning to the end of a project, by ensuring that the team is aware of, and addresses...

  • Principal Scientist/Senior Principal Scientist, Form Characterization

    5 days ago

    Summit, NJ, United States Bristol-Myers Squibb Full time

    Principal Scientist/Senior Principal Scientist, Form Characterization Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the...

  • Principal Material Scientist

    4 weeks ago

    Westwood, MA, United States enVerid Systems, Inc. Full time

    Position: Principal Material ScientistManager: Alex Goodwin, SVP Product and EngineeringLocation: Westwood, MA (Onsite)About the Company enVerid Systems is a leader in indoor air quality and energy efficiency for commercial buildings. Our Sorbent Ventilation Technology™ (SVT) improves indoor air quality, lowers a building’s carbon footprint, and reduces...

  • Principal Scientist or Sr. Principal Scientist

    5 days ago

    New Brunswick, NJ, United States Cfdv Full time

    Principal Scientist or Sr. Principal Scientist - Analytical Development Primary Location: New Brunswick, New Jersey or Summit, New Jersey We are seeking an experienced leader with strong analytical technical skills and a passion for strategic project leadership, mentoring others, and driving technical innovation to solve challenging problems. This role will...

  • Principal Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States The Accuro Group Full time

    Job OpportunityWe are seeking a highly skilled and experienced Principal Research Scientist to join our team at The Accuro Group in Cambridge, MA 02142.About the RoleThis is a contract position (12 months+) with opportunities for extended tenure. You will be working closely with our team to drive innovation and growth.Salary InformationThe estimated salary...

  • Principal AI Scientist

    5 days ago

    Denver, CO, United States Altamira Technologies Corp. Full time

    Altamira Technologies is seeking a Principal AI Scientist that possesses a mix of talent related to artificial intelligence / machine learning, data science, and traditional algorithms. In response to emergent customer requirements, the Principal AI Scientist leverages their understanding of national security missions to develop innovative and viable...

  • Principal Scientist, Analytical Development

    4 days ago

    Cambridge, MA, United States Aurion Biotech Full time

    JOB TITLE: Principal Scientist, Analytical Development LOCATION: Cambridge, MA SALARY RANGE: $163,000 to $180,000. The midpoint of the range is $170,000. The ideal candidate would be hired at or around the midpoint. ABOUT THE POSITION Aurion Biotech is seeking a highly motivated Principal Scientist, Analytical Development in Cambridge, MA. This position...

  • Principal Associate Scientist, Biology

    1 month ago

    Cambridge, MA, United States Alnylam Pharmaceuticals Full time

    OverviewThe Research Department at Alnylam is seeking an experienced Principal Associate Scientist to join an interdisciplinary team dedicated to broaden the preclinical application of the RNAi platform and extrahepatic siRNA delivery through in vitro and in vivo mechanistic studies. The role requires strong interpersonal skills, the capacity to multi-task,...

  • Principal Scientist mRNA

    4 days ago

    Cambridge, MA, United States GSK Full time

    At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. We believe the Greater Boston area is an important hub for the biotech and pharma industry,...

  • Principal Scientist- Global Regulatory Affairs-CMCS

    4 days ago

    , MS, United States Firefingrill Full time

    Position: Principal Scientist - Global Regulatory Affairs-CMC Purpose: The Principal Scientist-Global Regulatory Affairs-CMC role aims to provide strategic, tactical, and operational direction to expedite CMC development and technical agendas by supporting global clinical trial, market registration submissions, and post-approval submissions. This is...

  • Principal Scientist

    5 days ago

    Bridgewater Township, NJ, United States Nestlé SA Full time

    Principal Innovation Sensory Insights Scientist At Nestlé Health Science, we believe that nutrition, science, and wellness must merge, not collide. Here, we embrace the intrinsic connections of these three pillars, harnessing their collective strength to empower healthier lives. Our broad product portfolio includes renowned brands like Garden of Life,...

  • Principal Scientist

    4 days ago

    Coventry, RI, United States Pharmaron Beijing Co. Ltd. Full time

    We are seeking a Principal Scientist to join our team in Coventry, RI. The Principal Scientist, Analytical will spearhead manufacturing and process chemistry activities through the development, optimization, validation, and transfer of analytical methods, adhering to all relevant guidelines. Primary Responsibilities: Execute all tasks promptly and...

  • Senior Scientist/Principal Scientist, Biomarker Discovery and Data Science

    5 months ago

    Cambridge, United States Flagship Pioneering Full time

    Company Summary: Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as > 95% of global healthcare costs are spent on treating rather than preventing...

  • Principal Research Scientist I

    5 days ago

    , MA, United States Allergan Full time

    Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and...

  • Principal Data Scientist

    5 days ago

    Richmond, VA, United States Capital One Full time

    Locations: VA - McLean, United States of America, McLean, Virginia Principal Data Scientist Principal Data Scientist – Consumer Credit Risk Management Models and Data Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually personalizing every credit card offer using statistical modeling and the...

  • Principal Scientist, ADC Characterization

    1 month ago

    Boulder, CO, United States SciPro Full time

    SciPro is excited to share an extraordinary opportunity with our key client in Colorado who is seeking a Principal Scientist, ADC/Antibody Characterization to join their innovative team.This is not just another role—our client is backed by a former C-Suite executive from one of the largest global software companies, and they are at the forefront of...