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Senior Associate Scientist- Lysosomal Disease

3 months ago

Tarrytown, United States Regeneron Pharmaceuticals, Inc Full time

We are seeking an independent and motivated Senior Associate Scientist to join our Enzyme Replacement Therapies group. As a part of Regeneron Genetics Medicine group, you will support the development of ground breaking gene therapies for treating lysosomal diseases. You will contribute to the development of new therapies using our technology platforms, including blood-brain barrier crossing, gene therapy, CRISPR-mediated gene editing, VelociGene mouse models and VelocImmune antibody platforms. We hope you are excited by the opportunity to contribute to innovative projects and further expand our targeted drug delivery portfolio in a collaborative environment.

As a Sr. Associate Scientist, a typical day might include the following:

Planning and performing in vitro and in vivo experiments to validate the effectiveness of enzyme replacement therapies

Performing basic molecular biology techniques (Western blotting, ELISA, enzymatic activity assays, immunofluorescence staining, plasmid cloning)

Culturing mammalian cell lines, performing transient transfections and cell-based assays

Conducting in vivo gene therapy studies in mice, including dosing, harvesting, and analyzing tissues

Working collaboratively with other team members and providing support to their programs

Participation in team meetings and preparation of regular presentations for departmental meetings

This role might be for you if you:

Enjoy working in an innovative and highly collaborative environment

Have an avid interest in developing gene therapies for rare diseases

Have strong organizational, time-management, and communication skills

Can effectively balance multiple projects

In order to be considered for this role , you must have at least a BS/MS and 3+ years of relevant experience and expertise in mouse models of human disease, cell biology, molecular biology, or related fields. Must have experience performing mouse treatment studies, mammalian cell culture, Western Blot, and ELISA. Experience with AAV gene therapies and antibody therapies strongly preferred.