Senior Director, BBB Biology

6 hours ago


Cambridge, Massachusetts, United States 先声药业 Full time
Senior Director, BBB Biology

At Simcere Pharmaceutical Group, we are committed to "Providing Today's Patients with Medicines of the Future" across various core therapeutic areas. Our Boston Innovation Center is dedicated to developing groundbreaking technologies and transformative medicines in oncology, CNS disorders, and autoimmune diseases.

We are seeking a collaborative and innovative Senior Director to lead our BBB Biology team. The ideal candidate will possess a proven track record in advancing groundbreaking modalities for the treatment of CNS diseases. This role is based in Cambridge, MA, and reports to the VP of CNS Discovery.

Responsibilities:
  • Develop BBB-crossing treatments to provide high-value programs in line with Simcere's portfolio strategy.
  • Make strategic and quality decisions for the programs in alignment with Simcere's management teams.
  • Craft an innovative product profile and guide decision-making by formulating outcome scenarios at critical data inflection points.
  • Assemble and maintain a motivated and high-performing program team, ensuring team members meet their expectations.
  • Provide relevant input into other portfolio project teams when needed.
  • Establish and cultivate cross-functional relationships with internal stakeholders.
  • Provide oversight to collaborative programs and maintain strong relationships with investigators and key opinion leaders (KOLs) in the field, both nationally and internationally.
Qualifications:
  • PhD, MD or MD/PhD in neuroscience or related fields, with 8+ years of experience in BBB biology.
  • Must have experience in leading a group to study the delivery of large molecules across the BBB in industrial or academic settings.
  • Strong knowledge of preclinical and translational research, as well as early clinical development, is highly desirable.
  • Excellent communication and negotiation abilities, along with prior experience in leading organizations and guiding individuals through transformative changes.
  • Demonstrated success in building teams, leading and influencing experienced professionals and executives.
  • Ability to think critically, creatively and to anticipate and solve problems.


  • Cambridge, Massachusetts, United States Atlas Venture Full time

    About the RoleWe are seeking a highly motivated and experienced Senior Scientist to join our CNS Biology team at Atlas Venture. As a key member of our team, you will be responsible for designing and executing in vitro and in vivo studies to advance our RNA editing therapeutics for neurodegenerative diseases.Key ResponsibilitiesDesign and conduct RNA editing...


  • Cambridge, Massachusetts, United States American Society of Plant Biologists Full time

    About the RoleWe are seeking a highly skilled Senior Research Scientist, Plant Molecular Biology Specialist to join our team at the American Society of Plant Biologists. As a key member of our research team, you will be responsible for leading the development of our plant cell culture platform and driving innovation in plant molecular biology.Key...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    Position: Scientist / Senior Scientist – Computational BiologyCompany OverviewGC Therapeutics is a pioneering company focused on genome-wide cell landscape exploration, utilizing an integrated synthetic biology and AI-driven platform for cell programming. Our proprietary technology platform, TFomeTM, developed in the lab of Professor George Church, a...


  • Cambridge, Massachusetts, United States FogPharma Full time

    About the RoleFogPharma is a pioneering biopharmaceutical company that is revolutionizing the medical possibilities for patients by precisely drugging intracellular targets. We are seeking a highly motivated Senior Associate Scientist with experience in cellular and molecular biology techniques for drug discovery.Key ResponsibilitiesDevelop and Perform...


  • Cambridge, Massachusetts, United States Bayer Full time

    About the RoleWe are seeking a highly skilled and experienced Senior Director, Research Oncology to join our team at Bayer. As a key member of our Research and Early Development (RED) Oncology team, you will play a strategic role in guiding research and drug discovery programs in the oncology pipeline.Key ResponsibilitiesLead multiple drug discovery programs...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job SummaryWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage.Key Responsibilities:Lead and mentor a team of scientists in oncology drug discovery and early development.Develop and execute strategies to...


  • Cambridge, Massachusetts, United States Harvard University Full time

    Job SummaryWe are seeking a highly qualified and experienced Tenured Professor in Plant or Fungal Biology to serve as Director of the Harvard University Herbaria. The successful candidate will be responsible for leading the institution's scientific mission, contributing to broader biodiversity-centered efforts at Harvard, and teaching at both undergraduate...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job SummaryWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage. The individual will play a key role in advancing drug discovery programs as well as leading initiatives towards the inception and development...


  • Cambridge, Massachusetts, United States Novartis Full time

    About the RoleWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage. The individual will play a key role in advancing drug discovery programs as well as leading initiatives towards the inception and...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job DescriptionJob Summary:We are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage.About the Role:The individual will play a key role in advancing drug discovery programs as well as leading initiatives towards...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job Opportunity SummaryWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage.Key Responsibilities:Lead and mentor a team of scientists in oncology drug discovery and early development, with a focus on small...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job SummaryWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage. The individual will play a key role in advancing drug discovery programs as well as leading initiatives towards the inception and development...


  • Cambridge, Massachusetts, United States Bayer Full time

    Job SummaryBayer is seeking a highly skilled Senior Director, Companion Diagnostics Lead to execute global diagnostic strategies for our Precision Medicine portfolio. This role involves collaborating with diagnostic partners, IPT members, and other key stakeholders to drive the development of Companion Diagnostics with appropriate partners.Key...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job SummaryWe are seeking a highly driven professional with a strong cancer biology background and track record of successfully leading small molecule drug discovery projects from early to development candidate stage. The individual will play a key role in advancing drug discovery programs as well as leading initiatives towards the inception and development...


  • Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    Job DescriptionWe are seeking a highly experienced and skilled Senior Director/Vice President, CMC to join our team at Repertoire Immune Medicines. This is a unique opportunity to lead our CMC efforts and contribute to the development of novel targeted immune medicines.Key ResponsibilitiesBuild and lead effective CMC Teams to develop and optimize upstream...


  • Cambridge, Massachusetts, United States Bayer Full time

    About the RoleWe are seeking a highly experienced and skilled Senior Director, Companion Diagnostics Lead to join our team at Bayer. As a key member of our Precision Medicine team, you will be responsible for executing global diagnostic strategies for our Precision Medicine portfolio.Key ResponsibilitiesDevelop and implement comprehensive companion...

  • Research Associate

    1 week ago


    Cambridge, Massachusetts, United States GC Therapeutics Full time

    Job Title: Research Associate - In Vivo BiologyAbout GC TherapeuticsGC Therapeutics is a pioneering genome-wide cell landscape exploration company that leverages an integrated synthetic biology and AI-driven platform for cell programming. Our patent-pending and proprietary pluripotent stem cell differentiation technology platform, TFomeTM, was developed in...


  • Cambridge, Massachusetts, United States Volnay Therapeutics Full time

    Job DescriptionJob Title: Product Design DirectorCompany: Volnay TherapeuticsJob Type: Full-timeLocation: RemoteAbout Us:Volnay Therapeutics is a leading biotechnology company dedicated to developing innovative cell therapy products. We are seeking a highly skilled and experienced Product Design Director to lead our cell therapy research initiatives and...


  • Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    About the RoleWe are seeking a highly experienced and skilled Senior Director/Vice President, CMC to join our team at Repertoire Immune Medicines. As a key member of our organization, you will be responsible for advancing our TCR bispecific therapies from lead candidate to clinical development.Key ResponsibilitiesProcess Development and Optimization: Build...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    Job Title: Research Associate, In Vivo BiologyAbout the Role:GC Therapeutics is seeking a highly skilled and detail-oriented Research Associate to join our preclinical team. As a key member of our team, you will support the execution of in vivo studies, including rodent models, and contribute to the development of cell therapies.Key Responsibilities:Design,...