Associate Director, Protein Biochemistry

15 hours ago

Tarrytown, New York, United States BioSpace, Inc. Full time
Job Details

The Protein Biochemistry Group is seeking a highly motivated Associate Director to lead molecular profiling, developability, and characterization of therapeutic proteins, representing a variety of formats. In this exciting role, you will also provide matrix-based support for the characterization of novel modalities such as gene therapy agents and oligonucleotides as well as complex therapeutic strategies and approaches.

A Typical Day in the Role of Associate Director Might Look Like:
  • Participates in and oversees protein or new modality characterization to provide molecular profiles and developability assessments of therapeutic assets, that support the pipeline, in a timely manner and aligned with partner functions.
  • Understands current computational biophysics approaches (workflows, software) for building static and dynamic models (in silico profiles) that complement experimentally derived molecular data.
  • Reviews the literature and works with their team to design experiments that solve biophysical problems for key stakeholders.
  • Supervises and supports scientists with critical data review as well as career development. Builds an effective molecular characterization team.
  • Ability and enthusiasm for independently learning new methods and software. Is a go-to resource for explaining and solving biophysical problems.
  • Practical knowledge of downstream purification, analytical method, and formulation development of biologics and drug product profiles aligned with therapeutic strategies.

This Role Might Be For You If You:
  • Have in-depth knowledge of macromolecular physical chemistry, especially solution interactions, and hands-on experience in protein characterization using a variety of analytical tools.
  • Have established computational and molecular modeling experience to complement in silico-derived information with experimental data.
  • Are an effective communicator of ideas, project goals, and results to team members within the group and with colleagues in collaborating departments.
  • Can proactively identify issues and develop solutions in a collaborative multidisciplinary environment.

Requirements:
  • PhD in pharmaceutical sciences, biophysics, biochemistry, chemical engineering, or equivalent with at least 9 years post, post-doctoral training combined with industry experience in characterization of therapeutic protein candidates.
  • Extensive experience with computational biophysics and molecular static and dynamic modeling.
  • Practical experience with standard modeling software such as (but not limited to) Schrodinger (or MOE), Discovery Studio, Gromacs, Gaussian, etc.
  • Knowledge of and demonstrated expertise with light scattering, liquid chromatography, and capillary electrophoresis instrumentation is essential.
  • Experience in spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e.g. icIEF, IEX) separation techniques is important.
  • Mass spec experience a plus.
  • Experience of developing and troubleshooting analytical methods and must demonstrate the ability to plan, design, implement laboratory experimentation to advance projects, as well as experience with statistical and experimental design, molecular modeling, graphing, and mathematical analysis software is also important.

What We Offer:
  • Comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels.
  • An inclusive and diverse culture that provides opportunities for growth and development.

Regeneron is an Equal Opportunity Employer:
  • We are committed to diversity and inclusion and welcome applications from qualified candidates from all backgrounds.
  • We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.

Salary Range (annually):
$170,100.00 - $277,500.00

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