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Immunology Research Scientist

2 months ago

San Francisco, California, United States Site Therapeutics Full time
About Site Therapeutics

Site Therapeutics is a cutting-edge biotechnology company dedicated to revolutionizing the field of immunology and developing innovative therapeutics for autoimmune diseases. Our mission is to harness the power of genetic editing to create novel treatments that transform the lives of patients.

Job Summary

We are seeking a highly motivated and experienced Scientist/Senior Scientist to join our launch team and contribute to our groundbreaking research in immunology and functional genomics. As a key member of our team, you will play a pivotal role in developing and optimizing high-throughput assays, culturing primary human immune cells, and designing novel protocols for screening and validating novel targets.

Key Responsibilities
  • Prioritize and Develop Screening Phenotypes: Identify and prioritize screening phenotypes in primary immune cells with therapeutic translatability to human autoimmune disease.
  • Develop Immunological Assays: Design and develop immunological, biological, and biochemical assays to screen and validate novel targets and their associated mechanisms.
  • Optimize Cell Culture and Assays: Optimize primary human T cell and other lymphocyte or myeloid culture, and develop novel protocols and standard operating procedures (SOPs) associated with culturing, differentiating, and screening primary human immune cells.
  • Flow Cytometry and FACS: Perform flow cytometry and fluorescence-activated cell sorting (FACS) of primary human cells.
  • High-Throughput Screening: Design and optimize high-throughput base editing screens to identify sites on proteins with functional consequences in autoimmune relevant phenotypes.
  • Collaboration and Communication: Close collaboration with a team of Scientists and Research Associates to ensure timely completion of projects and creation of a large map of genomic sites impacting immune cells.
  • Staying Current with Emerging Literature: Stay up-to-date with emerging scientific literature and share ideas liberally.
Qualifications
  • Ph.D. in Immunology or Related Field: Ph.D. in immunology or a related field, with 0-3 or more years of laboratory (industrial or postdoctoral) experience.
  • Experience with Immunological Assays: Experience with immunological assay development and flow cytometry and/or FACS, with a preference for high-throughput methods.
  • Experience with Cell Culture: Experience with mammalian cell culture, with a preference for primary cells.
  • Excellent Communication Skills: Excellent organizational and interpersonal communication skills (verbal and written).
  • Ability to Learn and Adapt: Willingness and ability to learn new methods and skills for changing research priorities.
  • Scientific Excellence: Evidence of scientific excellence and impact as illustrated by scientific publications and presentations.
  • Attention to Detail: Ability to keep detailed and organized records of experimental protocols and results.
  • Team Player: Ability to work independently and as a member of a research team.
  • Time Management: Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
  • Leadership Potential: Self-starter with an interest in building a team from the ground up at a brand new start-up.
What We Offer

In addition to a competitive compensation package with stock options, we offer comprehensive health, dental, and vision benefits, plus a 401K and 3% employer contribution for employees and their families.

We believe that a diverse, open, and inclusive environment and culture is key to our success. We are committed to creating a workplace where everyone feels valued, respected, and empowered to contribute their best work.