Senior Scientist I-II

1 week ago

San Diego, California, United States ADARx Pharmaceuticals Inc. Full time
Job Opportunity

Senior Scientist I-II – Discovery Chemistry – Conjugation

Job Summary:

We are seeking a highly skilled and experienced Senior Scientist I-II to join our Discovery Chemistry Department as part of a dynamic team driving success in RNA-based drug discovery projects. The ideal candidate will possess a strong background in bioconjugation, purification, and analytical techniques, with a proven track record of generating high-quality data in a fast-paced research environment.

Key Responsibilities:

  • Design, develop, and optimize conjugation protocols using novel chemistries and techniques.
  • Perform bioconjugation, purification, and characterization of novel conjugates involving oligonucleotides and other modalities.
  • Collaborate with cross-functional teams to drive project success and generate regular status updates.
  • Contribute to the preparation of research reports and presentations for internal project teams, leadership, and external audiences.
  • Maintain updated and well-organized lab notebooks and manage equipment, reagents, and the dedicated laboratory environment.
  • Execute daily chemistry operations with an approach designed to minimize risks and hazardous waste streams.
  • Maintain all appropriate corporate standards for lab safety and hazardous material management.

Requirements:

  • Ph.D. in Chemistry, Biochemistry, or a related scientific discipline.
  • Minimum of 2-5 years of biotech/pharmaceutical industry experience in bioconjugation.
  • In-depth knowledge of modern bioconjugation methods, purification, and analytical techniques.
  • Hands-on experience with oligonucleotide bioconjugation; previous experience in peptide and antibody-drug conjugation is preferred.
  • Proficiency in purification techniques such as RP-HPLC, FPLC, size exclusion chromatography (SEC), and ion exchange chromatography (IEX).
  • Strong background in the analytical characterization of oligonucleotide conjugates, especially RP-HPLC and LC-MS.
  • Excellent written and verbal communication skills and effective presentation of complex scientific data.
  • Superior laboratory skills and awareness of laboratory safety.

Preferred Qualifications:

  • 5+ years of experience in biotech/pharmaceutical industry.
  • A track-record of impacting drug discovery programs through driving projects to key decision points.
  • Broad knowledge of scientific experience with track record of scientific achievement demonstrated by peer-reviewed publications.

Work Environment:

ADARx Pharmaceuticals, Inc. is a clinical stage biotechnology company committed to turning cutting-edge science into life-saving therapeutics. We are well-financed by a syndicate of renowned VC firms and have a growing pipeline of RNA targeting therapeutics for treating diseases across a range of therapeutic areas.

Equal Employment Opportunity:

ADARx Pharmaceuticals, Inc. is an EEO employer committed to an exciting, diverse, and enriching work environment. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Compensation and Benefits:

  • This is a full-time position, Monday-Friday, occasional overtime.
  • Pay is commensurate with experience.
  • Equity-based compensation
  • Performance-based bonuses
  • 401(k) with Company Match
  • Medical, Dental, Vision
  • Flexible Spending Account
  • Life Insurance
  • Employee Assistance Program
  • Employee Discounts
  • Gym Membership
  • Paid Vacation
  • Paid Holidays
  • Paid Sick, Jury Duty, Bereavement

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