Senior Scientist, Next-Generation Sequencing Specialist

1 week ago

Cambridge, Massachusetts, United States HireMinds Full time

Job Summary:

HireMinds is seeking a highly skilled Senior Scientist, Next-Generation Sequencing Specialist to join our pioneering team in the gene editing world. As a key member of our team, you will play a pivotal role in advancing genomics solutions, from developing cutting-edge NGS assays to characterizing genome editing outcomes.

Key Responsibilities:

  • Develop and Implement NGS-Based Assays: Design, optimize, and implement NGS-based assays, such as amplicon sequencing, single-cell genomics/transcriptomics, long reads, and emerging sequencing technologies.
  • Stay Up-to-Date with NGS Advancements: Keep abreast of advancements in NGS technologies and contribute strategically to their application to daily workflows.
  • Conduct Wet Lab Experiments: Design, conduct, and troubleshoot wet lab experiments involving sample preparation, library construction, and sequencing.
  • Collaborate with Computational Sciences: Work closely with computational sciences to assess data quality, facilitate data interpretation, and innovate analysis pipelines.
  • Refine Workflows and Pioneer Next-Generation Systems: Collaborate with high throughput amplicon sequencing teams to refine workflows and pioneer next-generation systems, including single-cell RNAseq, AMP-seq, and other platforms.
  • Scale New Assays Effectively: Partner with automation, software engineering, and computational sciences to scale new assays effectively.
  • Mentor and Guide Junior Scientists: Mentor and guide junior scientists, fostering a collaborative and growth-oriented team environment.
  • Document Experimental Procedures: Document experimental procedures, maintain meticulous lab records, and prepare technical reports and presentations.

Requirements:

  • PhD in Genomics with 1-4 years of relevant experience, OR MS with ~8 years equivalent industry Biotech/Pharmaceutical setting experience.
  • Laboratory Hands-On Expertise: Laboratory hands-on expertise in NGS library construction, quantification, sequencing, and data analysis.
  • Mentoring and Management Experience: Demonstrated experience in mentoring or managing junior scientists as a hands-on member of the lab team.
  • Automation and Genome Editing Knowledge: Familiarity with liquid handling automation, particularly with Hamilton systems, is desirable. Knowledge of genome editing technologies, such as CRISPR, would be advantageous.
  • Excellent Communication and Organizational Skills: Excellent communication, documentation, and organizational skills, coupled with exceptional time management and attention to detail.
  • Collaborative Mindset: A collaborative mindset with the ability to thrive in interdisciplinary teams.

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