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Senior Scientist, Display Technologies Expert
2 months ago
Fable Therapeutics is a pioneering biotechnology company that leverages cutting-edge protein language models to develop innovative biologics. Our mission is to revolutionize protein-based therapeutics by harnessing the power of AI and computation.
Job SummaryWe are seeking a highly skilled Senior Scientist to join our team and establish our in-house display technologies capabilities. As a key member of our discovery team, you will be responsible for identifying progressable hits from our bespoke AI-designed antibody libraries using eukaryotic display technologies or high-throughput antibody generation and screening.
Key Responsibilities- Design and implement synthetic antibody libraries from AI-designed sequences
- Select hits using mammalian display, yeast display, or other display technologies as appropriate
- Analyze DNA sequences and perform Next Generation Sequencing (NGS) for hit validation
- Subclone hits into mammalian expression vectors and express and purify antibody constructs in mammalian cell culture
- Utilize liquid handlers and automation for high-throughput expression and purification of antibodies
- Perform binding assays using FACS, flow cytometry, and ELISA
- Document and record scientific results, uploading data to databases and LIMS systems
- Curate data for ingestion and utilization by ML scientists
- Mentor and train junior scientists
- PhD or postdoc in Protein Engineering or Protein Chemistry with 4+ years of industry experience in biologics discovery and protein science, or MSc with 6+ years of experience
- Proven track record in biologics hit discovery, affinity maturation, and lead optimization
- Excellent protein engineering skills and display technologies expertise
- Experience with flow cytometry/FACS instruments and liquid handling systems
- Familiarity with high-throughput screening systems and digital workflows
- Ability to work efficiently in a close-knit team and deliver high-quality, reproducible data in a fast-paced environment
- Attentive to detail and a careful experimenter
- Ability to take initiative and improve processes
- Excellent communicator and presenter of scientific data
- Passionate about the power of AI to transform biotherapeutics
- Focused on quantifiable results and data-driven decisions
- Collaborative and inclusive mindset
Fable Therapeutics is an equal opportunity employer and values diversity and inclusion. We provide a supportive and collegial work environment where we empower our people to develop their long-term careers.
