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Lead RNA Editing Scientist
2 months ago
Korro Bio, Inc. is a pioneering biopharmaceutical organization dedicated to the advancement of a novel category of genetic therapies targeting both rare and widespread diseases through its innovative RNA editing technology.
Korro is developing a diverse array of unique programs aimed at leveraging the body's inherent RNA editing mechanisms to achieve precise yet temporary single base modifications.
By focusing on RNA rather than DNA, Korro is broadening the scope of genetic therapies, offering enhanced precision and flexibility, which may lead to greater specificity and improved long-term tolerability.
Utilizing an oligonucleotide-centric strategy, Korro aims to deliver its therapies to patients by capitalizing on its proprietary platform, established delivery methods, manufacturing expertise, and recognized regulatory pathways associated with approved oligonucleotide treatments.
Korro's primary therapeutic focus is on Alpha-1 Antitrypsin Deficiency (AATD).
We are a collaborative organization united by a shared mission.
We are committed to assembling a team of exceptional individuals with an ambitious vision to develop transformative genetic therapies for common diseases.
Our core values - Rewrite the Future, On the Cutting Edge, Better Together, Dynamically Different, Kindness, and Integrity - are integral to our culture.
These values are reinforced daily and play a crucial role in our hiring process, ensuring that Korro attracts outstanding talent and fosters a positive work environment.
As we redefine the possibilities in genetic medicine, we strive to make a significant impact on human health.
Position Overview:We are in search of a highly driven and seasoned Principal Scientist to become a key member of our Platform team.
This laboratory-based role will concentrate on enhancing our understanding of ADAR biology and biochemistry through a range of biochemical, cellular, and molecular assays.
The selected candidate will take charge of investigational initiatives, encompassing the design and execution of assays, data analysis, interpretation, and presentation to the broader team.
The ideal candidate will demonstrate expertise in various biochemical, structural, and/or cell-based assays.
We seek a motivated team player with a proven track record of mentoring and guiding junior scientists, possessing excellent interpersonal and communication skills, and the ability to manage multiple high-priority tasks.
Key Responsibilities:
Independently design, execute, and troubleshoot an array of biochemical and cell-based assays to advance the company's understanding of oligo-directed RNA editing, including but not limited to enzyme kinetics, protein purification, protein binding assays (SPR, fluorescence polarization), structural biology, molecular modeling, SHAPEmap and RNA folding, LC-MS, cell-based assays, RNA isolation, Western blotting, qPCR, dPCR, and NGS.
Analyze intricate data sets and effectively communicate findings while leading the decision-making process for future scientific endeavors.
Proactively develop and implement innovative technical solutions to propel the company forward, staying informed on relevant scientific literature and the competitive landscape.
Lead cross-functional teams, applying knowledge and expertise to define project scope and objectives while providing mentorship to junior team members.
Identify, establish, and lead external collaborations and projects with academic institutions and contract research organizations (CROs).
Required Qualifications:
- PhD with 5+ years of industry experience; MS with equivalent years of industry experience in biochemistry, cell biology, or a related field.
- Proven ability to independently drive high-level projects forward.
- Capacity to learn and implement new techniques and adapt swiftly.
- Exceptional attention to detail, time management, and documentation skills.
- Ability to analyze, report, and communicate data rigorously.
- Demonstrated experience in mentoring and managing research assistants and scientists.
- Capability to multitask and effectively collaborate with a diverse team of scientists to deliver quality data and results.
Experience with oligonucleotide-based therapeutics.
Familiarity with ADAR biology/biochemistry.
Experience with CryoEM and/or X-ray crystallography.
Candidates who are enthusiastic experimentalists, independent thinkers, and collaborative team players with a passion for drug discovery are encouraged to consider this opportunity.
Korro offers competitive compensation, including equity-based incentives, along with a comprehensive benefits package that encompasses medical, dental, vision, a 401(k) retirement plan, life insurance, a dependent care flexible spending account, and a company-funded health savings account.
