RNA Synthesis Associate Scientist II

4 days ago


Cambridge, Massachusetts, United States Alnylam Pharmaceuticals Full time
Job Summary

We are seeking a highly motivated Associate Scientist II to join our RNA Synthesis group and support RNAi-based research and drug discovery. The successful candidate will design, synthesize, and purify oligonucleotides for research studies, and evaluate new chemical modifications for their use in the RNAi pathway.

Key Responsibilities
  • Design and develop novel synthetic methods and processes to expand the current capabilities of oligonucleotide synthesis.
  • Analyze and interpret analytical data to present to team members and inform research decisions.
  • Collaborate with team members to foster communication, efficiency, and culture, and effectively work in a highly interdisciplinary environment.
  • Develop and implement new chromatographic methods, such as IEX/RP HPLC, SPE, and LC-MS, to improve the synthesis and purification of oligonucleotides.
  • Utilize analytical instrumentation, such as UV-Vis spectroscopy, HPLC, and LC-MS, to analyze and characterize synthetic oligonucleotides.
Requirements
  • Bachelor's or Master's degree in Chemistry, Biochemistry, or a related field.
  • 0-4 years of work experience, preferably in an industrial setting.
  • Experience in solid-phase synthesis of biomolecules and a good understanding of the procedures involved in SPS.
  • Experience with instrumentation such as HPLC, LC-MS, UV-Vis spectrometry, etc.
  • Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently.
About Alnylam

Alnylam Pharmaceuticals is a leader in the development of RNAi therapeutics, with a commitment to innovative science and a passion for excellence. Our culture is guided by core values of innovation, openness, urgency, excellence, and commitment to people. We are proud to be recognized as a top employer and a leader in the biopharmaceutical industry.



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