RNA Synthesis Associate

5 days ago


Cambridge, Massachusetts, United States Alnylam Pharmaceuticals Full time
Job Title: Associate Scientist II, RNA SynthesisJob Summary

We are seeking a highly motivated Associate Scientist II to join our RNA Synthesis group and support RNAi-based research and drug discovery. The successful candidate will design, synthesize, and purify oligonucleotides for research studies, as well as evaluate new chemical modifications for their use in the RNAi pathway.

Key Responsibilities
  • Design and synthesis of chemically modified oligonucleotides
  • Improvement and development of new synthetic methods and processes
  • Analysis of oligonucleotides using UV-Vis spectroscopy, HPLC, and LC-MS
  • Troubleshooting and problem-solving
  • Development of new methods and automation for downstream processing of synthetic oligonucleotides
  • Analysis and interpretation of analytical data
Qualifications
  • Bachelor's or Master's degree in Chemistry, Biochemistry, or a related field
  • 0-4 years of work experience, preferably in an industrial setting
  • Experience in solid-phase synthesis of biomolecules and instrumentation such as HPLC, LC-MS, UV-Vis spectrometry
  • Ability to work within a highly interdisciplinary environment
  • Excellent written and oral communication skills
About Alnylam

Alnylam Pharmaceuticals is a leader in the translation of RNA interference (RNAi) into innovative medicines. Our RNAi therapeutics represent a powerful approach to treating diseases at their genetic source. We are committed to an inclusive recruitment process and equal employment opportunity, and we strive to create an environment where employees can feel that they belong and achieve to their full potential.



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