Senior Scientist, Gene Editing
4 weeks ago
Editas Medicine is pioneering the possible by harnessing the potential of CRISPR/Cas12a and CRISPR/Cas9 genome editing systems to develop transformative medicines for people living with serious diseases.
About the RoleWe are seeking an experienced Associate Scientist, Platform Technology to join our team. As a key contributor to our mission, you will design, execute, and analyze high-throughput screens using various CRISPR delivery systems to identify lead guides across our internal and external programs.
Key Responsibilities- Design and run screening experiments, extract gDNA, submit for sequencing, analyze, and present data
- Implement a high-throughput LNP screening workflow, including automated LNP-formulations
- Assist with RNP complexation and perform QC for internal program use
To thrive in this role, you'll need:
- B.S. in cell biology, or related field with 5+ years of relevant experience in industry; or M.S. in cell or molecular biology with 2+ years of relevant experience in industry
- Experience with mammalian cell culture, including immortalized and primary cells (ex. Liver Cells and HSCs)
- Proficient in executing and analyzing functional assays including flow cytometry and western blots
- Experience working with different screening modalities such as guide RNAs and LNPs and knowing how to formulate both RNP and LNPs
- Experience with data analysis software such as PRISM, Tableau, and FlowJo
- Familiar in molecular biology analyses such as qPCR and ddPCR
- Familiar working with lab automation including both liquid handling robots (Biomek I7s, Mantis, Echo) and plate readers (Envision)
- Excellent communication and interpersonal skills fostering effective teamwork
Editas Medicine provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
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