Senior Computational Chemist

5 days ago


San Francisco, California, United States Generalproximity Full time
About General Proximity

We are a pioneering biotechnology company dedicated to developing innovative medicines that address some of the most pressing healthcare challenges. Our mission is to harness the power of induced-proximity technologies to create life-saving treatments for patients in need.

Job Summary

We are seeking an experienced Senior Computational Chemist to join our Drug Discovery Team. As a key member of our team, you will play a critical role in designing and optimizing novel therapeutics using cutting-edge computational chemistry approaches.

Key Responsibilities
  • Develop and implement advanced computational models to predict protein-ligand interactions and design novel molecules
  • Collaborate with our Medicinal Chemistry Team to optimize lead compounds and advance them through the drug discovery pipeline
  • Apply machine learning and artificial intelligence techniques to analyze large datasets and identify patterns that inform drug design
  • Work closely with our Structural Biology Team to integrate experimental data and validate computational predictions
  • Contribute to the development of our OmniTAC drug discovery engine and other induced-proximity technologies
Requirements
  • PhD in Computational Chemistry, Medicinal Chemistry, Chemical Biology, or related field
  • 5-10+ years of industry experience in computational chemistry and drug discovery
  • Expertise in creating homology models, predicting protein-protein interaction interfaces, and docking small molecules
  • Experience with lead identification and lead optimization of diverse therapeutic modalities
  • Programming proficiency in Python and experience manipulating large datasets
  • Evidence of creative application of computational chemistry approaches to problems of biological interest, demonstrated through multiple publications and external presentations
Preferred Qualifications
  • Molecular dynamics drug discovery experience
  • Familiarity with Linux and high-performance computing
  • Experience applying computational methods such as molecular dynamics, quantum chemistry, and deep learning to problems of biological interest
  • Ability to use molecular modeling packages such as MOE, Schrödinger, PyMOL, and OpenEye
  • Experience with cheminformatics tools such as DataWarrior, Spotfire to analyze and visualize data
What We Offer
  • Competitive salary and equity incentives
  • Top-tier medical, dental, and vision coverage
  • One Medical membership
  • Education and health/fitness incentive programs
  • Meditation retreats
  • Reading budget
  • Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators


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