Computational Chemist – Director

4 days ago


San Diego, California, United States Klein Hersh International Full time
About the Role

We are seeking a highly skilled and experienced Computational Chemist to join our team at Klein Hersh International. As a key member of our drug discovery team, you will play a critical role in the analysis of newly discovered functional sites in proteins and contribute to the development of small molecules targeting various classes of targets.

Key Responsibilities
  • Strategic Planning: Develop and implement computational chemistry strategies to investigate newly discovered functional sites, leveraging a deep understanding of target biology and applying various tools of protein modeling.
  • Library Design: Drive the design of proprietary chemical libraries to improve screening outcomes, utilizing expertise in chemoinformatics and library design.
  • Virtual Screening: Employ structure/ligand virtual screening and AI methodologies to accelerate hit identification and hit-to-lead progression, staying up-to-date with the latest scientific literature and computational methodologies.
  • Collaboration: Engage with our biologists to ensure biological insights are incorporated into screening campaigns and SAR activities, fostering a culture of teamwork and scientific excellence.
  • Technical Expertise: Provide technical expertise and constructive feedback to other computational stakeholders, helping to develop an analytically-informed culture in collaboration with the Data Sciences team.
  • Drug Discovery: Collaborate with all functions to become an active participant of drug discovery from site identification to candidate nomination, staying current on scientific literature and emerging trends.
Requirements
  • Education: PhD degree in computational biology or chemistry with 5+ years of relevant experience within the biotech industry and a proven record of success in the development of therapeutic molecules.
  • Technical Skills: Competency with scientific scripting/programming, including proficiency with the Schrödinger suite of software and FEP methodologies.
  • Expertise: In-depth knowledge of quantum mechanics, QM/MM, and modeling protein-protein and protein-ligand interactions, as well as chemoinformatics and library design.
  • Soft Skills: Excellent organizational and communication skills, with the ability to work effectively to manage multiple parallel projects and critical evaluation and interpretation of scientific data.


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