Vice President of Chemistry and Drug Development

22 hours ago

San Francisco, California, United States Rezotx Full time
About Rezo

Rezo is a pioneering biopharma company dedicated to revolutionizing the drug development process. Our mission is to create a disease-agnostic, fully-integrated network biology platform that will redefine our understanding of human disease and treatment.

Our founders and board members are esteemed world-class scientists from the University of California, San Francisco, bringing with them a strong track record of scientific breakthroughs and successful companies. We are leveraging a unique integrated approach, combining genetics, proteomics, structural biology, and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco's vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, urban amenities, and outdoor recreational opportunities. We value a diverse, equitable, and inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state, or local laws.

The Opportunity

We are seeking a strong and motivated Vice or Senior Vice President of Chemistry to lead our medicinal chemistry team in San Francisco and leverage external CRO partnerships to achieve project goals and timelines. This position is an excellent opportunity to be on the ground floor and help build this function from the very beginning.

Key Responsibilities:
  • Lead multi-disciplinary drug discovery and development teams to IND-stage
  • Build and lead a medicinal chemistry team in San Francisco and leverage external CRO partnerships to achieve project goals and timelines
  • Develop and implement strategies to discover novel therapeutics, providing subject matter expertise in the field of chemistry with particular emphasis on first-in-class targets and emerging therapeutic modalities
  • Design high-quality small molecules considering SBDD, biological readouts, physicochemical properties, and pharmacological readouts
  • Build, maintain, and grow productive relationships with internal and external colleagues in chemistry, structural biology, pharmacology, and computational biology
  • Establish the intellectual property strategy working with internal and external patent counsel and lead the preparation of patent documents
  • Provide leadership for peer-reviewed scientific publications and content for the non-clinical sections of regulatory submissions relevant to chemistry
About You:

We are seeking a PhD in Chemistry or related area with 12+ years of experience in a biotech or pharmaceutical organization building teams and leading a group of chemists. Strong medicinal chemistry skills with a proven track record of successfully driving campaigns in small molecule chemistry are required. Experience in the design and implementation of heterobifunctional molecules and molecular glues is highly desirable.

Demonstrated experience in lead identification to IND application, knowledge of biophysical characterization techniques, and strong understanding of cGMP manufacturing guidelines are also essential. Proven leadership and excellent communication, organizational, and interpersonal skills are required. Experience managing academic and industrial external partners for outsourcing, licensing, and technology transfer is highly desirable.

Strategic thinker capable of prioritizing and implementing the Foundation's significant resources and the ability to influence/impact our mission is a must. A team player with strong organizational and multi-tasking skills is also required. Excellent written and oral communication skills are essential.

Compensation and Benefits

The expected starting salary range for this position based in San Francisco, California is $240,000-$360,000 for Vice President and $270,000-$400,000 for Senior Vice President. Actual starting salary will be determined based on multiple job-related factors including a candidate's skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity.

This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance, discretionary time off policy, company holidays (including summer and winter shutdown), 401(k) retirement savings program, parental leave, and competitive compensation are offered to our employees.

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