Vice President of Chemistry

1 day ago


San Francisco, California, United States Rezo Therapeutics Full time
About Rezo Therapeutics

We are a biopharma company that is redefining the way we approach drug development. Our mission is to increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform.

Our team is comprised of world-class scientists from the University of California, San Francisco, who bring a strong track record of scientific breakthroughs and successful companies. We are leveraging a unique integrated approach, combining genetics, proteomics, structural biology, and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco's vibrant Mission Bay neighborhood, we are in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons.

The Opportunity

We are seeking a strong and motivated Vice or Senior Vice President of Chemistry to lead our medicinal chemistry team. This position is an excellent opportunity to be on the ground floor and help build this function from the very beginning.

Key Responsibilities:
  • Lead multi-disciplinary drug discovery and development teams to IND-stage.
  • Build and lead a medicinal chemistry team in San Francisco and leverage external CRO partnerships to achieve project goals and timelines.
  • Develop and implement strategies to discover novel therapeutics, providing subject matter expertise in the field of chemistry.
  • Design high-quality small molecules considering SBDD, biological readouts, physicochemical properties, and pharmacological readouts.
  • Build, maintain, and grow productive relationships with internal and external colleagues in chemistry, structural biology, pharmacology, and computational biology.
  • Establish the intellectual property strategy working with internal and external patent counsel and lead the preparation of patent documents.
  • Provide leadership for peer-reviewed scientific publications and content for the non-clinical sections of regulatory submissions relevant to chemistry.
About You:

We are looking for a PhD in Chemistry or related area with 12+ years of experience in a biotech or pharmaceutical organization building teams and leading a group of chemists. You should have strong medicinal chemistry skills with a proven track record of successfully driving campaigns in small molecule chemistry.

Experience in the design and implementation of heterobifunctional molecules and molecular glues is highly desirable. You should have demonstrated experience in lead identification to IND application and experience in taking on challenging new targets and the ability to adopt new approaches and therapeutic modalities.

You should have knowledge of biophysical characterization techniques including DLS, NTA, HPLC, CE, DSC, DSF, et al. and a strong understanding of cGMP manufacturing guidelines.

Proven leadership and excellent communication, organizational, and interpersonal skills are essential. Experience managing academic and industrial external partners for outsourcing, licensing, and technology transfer is also desirable.

What We Offer

We offer a competitive compensation package, including a salary range of $240,000-$360,000 for Vice President and $270,000-$400,000 for Senior Vice President. We also offer a comprehensive benefits package, including medical, dental, and vision insurance, discretionary time off policy, company holidays, 401(k) retirement savings program, commuter/mass transit benefit program, healthcare flexible spending account, dependent care flexible spending account, parental leave, and flexible work schedule.



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