Vice President of Chemistry

5 days ago

San Francisco, California, United States Rezo Therapeutics Full time
About Rezo Therapeutics

We are a biopharma company that is revolutionizing the way we approach drug development. Our mission is to create a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.

Our Team

Our team is comprised of world-class scientists from the University of California, San Francisco, including Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, George Scangos, and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA-approved drugs.

The Opportunity

We are seeking a strong and motivated Vice or Senior Vice President of Chemistry to join our team. This position is an excellent opportunity to be on the ground floor and help build this function from the very beginning.

Key Responsibilities:
  • Lead multi-disciplinary drug discovery and development teams to IND-stage
  • Build and lead a medicinal chemistry team in San Francisco and leverage external CRO partnerships to achieve project goals and timelines
  • Develop and implement strategies to discover novel therapeutics, providing subject matter expertise in the field of chemistry with particular emphasis on first-in-class targets and emerging therapeutic modalities such as degraders, other bi-steric molecules, and covalent inhibitors
  • Design high-quality small molecules considering SBDD, biological readouts, physicochemical properties, and pharmacological readouts
  • Build, maintain, and grow productive relationships with internal and external colleagues in chemistry, structural biology, pharmacology, and computational biology
  • Establish the intellectual property strategy working with internal and external patent counsel and lead the preparation of patent documents
  • Provide leadership for peer-reviewed scientific publications and content for the non-clinical sections of regulatory submissions relevant to chemistry (e.g., information relevant to drug synthesis, formulation, analytical methods, and manufacturing processes)
About You:
  • PhD in Chemistry or related area with 12+ years of experience in a biotech or pharmaceutical organization building teams and leading a group of chemists
  • Strong medicinal chemistry skills with a proven track record of successfully driving campaigns in small molecule chemistry. Experience in the design and implementation of heterobifunctional molecules and molecular glues is highly desirable
  • Demonstrated experience in lead identification to IND application
  • Experience in taking on challenging new targets and the ability to adopt new approaches and therapeutic modalities
  • Knowledge of biophysical characterization techniques including DLS, NTA, HPLC, CE, DSC, DSF, et al.
  • Strong understanding of cGMP manufacturing guidelines
  • Proven leadership and excellent communication, organizational, and interpersonal skills
  • Extensive experience in small molecule drug discovery and a demonstrated track record of bringing small molecules from discovery to the clinic
  • Familiarity with the application of cutting-edge molecular design tools, advanced synthesis routes, modern chemical biology techniques, and efficient purification approaches
  • Experience managing academic and industrial external partners for outsourcing, licensing, and technology transfer
  • Experience in chemical biology and the integration of structural biology and biophysics across mechanistic biology and drug development
  • Experience in virtual screening and AI
  • Strategic thinker capable of prioritizing and implementing the Foundation's significant resources and the ability to influence/impact our mission
  • A team player with strong organizational and multi-tasking skills
  • Excellent written and oral communication skills
Compensation and Benefits

The expected starting salary range for this position based in San Francisco, California is $240,000-$330,000 for Vice President and $270,000-$370,000 for Senior Vice President. Actual starting salary will be determined based on multiple job-related factors including a candidate's skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

We offer a comprehensive benefits package, including medical (HMO or PPO), dental, and vision insurance, discretionary time off policy, company holidays (including summer and winter shutdown), 401(k) retirement savings program, commuter/mass transit benefit program, healthcare flexible spending account (FSA), dependent care flexible spending account (FSA), parental leave, competitive compensation, and flexible work schedule.

EEOC

At Rezo, we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.

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