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Pharmacology Program Manager

2 months ago

Madison, Wisconsin, United States Arrowhead Pharmaceuticals Full time

About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals is a clinical stage biopharmaceutical company that specializes in developing innovative medicines to treat complex diseases. Our mission is to harness the power of RNA interference to silence the genes that cause debilitating conditions.

Our Approach

We employ a unique approach to drug development, leveraging our proprietary RNAi technologies to target genes involved in disease. Our therapies trigger the natural RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes, offering a promising solution for diseases with a genetic basis.

Our Pipeline

Our clinical pipeline includes disease targets in the liver and lung, with a promising pipeline of preclinical candidates. We are committed to advancing our pipeline and bringing new therapies to patients in need.

The Position

We are seeking an experienced Clinical Pharmacologist to lead our Clinical Pharmacology/Pharmacometrics function for multiple programs in Phase 1-3 development. The ideal candidate will have a strong track record in clinical pharmacology program leadership and a deep understanding of drug development from pre-IND to NDA/BLA.

Responsibilities

  • Lead the development of clinical pharmacology strategies for multiple programs
  • Contribute to clinical protocol design and execution, and analyze data to prepare clinical study reports
  • Participate in regulatory interactions with global health authorities and prepare documents for submission
  • Maintain a current understanding of field literature for oligonucleotide therapeutics and Model-Informed Drug Development (MIDD)
  • Provide PK/PD modeling and simulations to support dosing strategies for clinical programs
  • Provide leadership expertise and mentor junior team members

Requirements

  • PhD or equivalent in pharmacokinetics, pharmacology, or pharmaceutical science
  • Track record in clinical pharmacology program leadership with 7+ years of pharmaceutical/Biotech industry experience
  • Established knowledge of drug development from pre-IND to NDA/BLA
  • Ability to apply scientific principles to complex situations and provide effective solutions
  • Strong verbal communication and document writing skills with clarity of thinking
  • Proficiency in non-compartmental analysis of clinical PK data

Preferred

  • Skills in population PK and PD modeling

Compensation

Arrowhead Pharmaceuticals offers a competitive salary range of $220,000—$300,000 USD, as well as an excellent benefit package.