Research Fellow DoM AbuGoot Lab

4 days ago

Cambridge, Massachusetts, United States Brigham & Women's Hospital(BWH) Full time

The AbuGoot lab at Brigham and Women's Hospital, Harvard Medical School, and Beth Israel Deaconess Medical Center is seeking a highly motivated postdoctoral associate to join the team and contribute to the study of blood regeneration using advanced perturbation tools and single-cell techniques.

We are interested in fundamental and universal mechanisms of aging and using functional genomics to discover new targets and modalities for extending lifespan with regards to rejuvenation of haemopoietic stem cells and downstream cell types.

This is a unique opportunity for you to work with cutting-edge technology development initiatives within the AbuGoot lab, focusing on stem cell biology, regenerative medicine, gene therapy, cell therapy, and advanced machine learning approaches.

The project is highly collaborative with other experimental and computational lab members.

The AbuGoot lab is a fast-paced and energetic group working at the frontier of molecular tool development.

We actively encourage creativity and leadership from our postdoctoral fellows, who generally will lead multiple projects and teams within the lab.

Responsibilities will include molecular cloning, protein design, bacterial assays, mammalian cell culture, directed evolution, and animal work; working closely with research technicians, postdocs, bioinformaticians, students, and principal investigators; engaging with the scientific community through collaborations, conference talks, and publications.

The position is ideal for someone interested in making a major impact in the cellular engineering and regenerative medicine fields while working in a fast-paced environment with a creative team.

We are looking for a highly motivated and skilled individual with a Ph.D. in biological sciences, engineering, or a related field; experience with mammalian cell culture, DNA assembly and characterization, high-throughput screening, molecular biology, lentiviral production, and animal work; ideally some HSC experience; self-motivation; ability to prioritize and perform multiple tasks in a dynamic, multidisciplinary, team-oriented setting; strong analytical, problem-solving, documentation, organizational, and interpersonal skills; desire to be an integral part of a cutting-edge research team; and ability to execute detailed technical protocols meticulously.

Flow cytometry, genetic engineering, aging research experience, and programming skills would be ideal.

Key Responsibilities:

  • Independently perform research projects in collaboration with other teams in the lab and the principal investigators.
  • Independently execute on experimental design, setting up stem cell models, genome-scale screening, and data analysis.
  • Collaborate with computational members to process data and evaluate predictions.
  • Manage a team of other technicians and students to execute the project.
  • Communicate data in weekly meetings and conferences.
  • All other duties as assigned.

Qualifications:

  • Scientific or engineering graduate degree in the areas of biology, bioengineering, or a related field in biological/physical sciences.
  • Experience with HSCs or related cell types is ideal.
  • A minimum of 2-4 years of relevant graduate research experience; can be 0-2 years of experience if with Master's degree.

Skills/Abilities/Competencies Required:

  • High degree of computer literacy.
  • Knowledge and experience with relevant techniques in biology, such as stem cell maintenance, genomics screening, and data analysis.
  • Sound analytical and organizational skills.
  • Requires good oral and written communication skills.
  • Must be able to logically and effectively structure tasks and set priorities.
  • Ability to identify potential problems and trouble-shoot solutions.
  • Demonstrated ability to analyze data statistically and to logically present it.
  • Drive to execute independent project.
  • The desire to be an integral part of a cutting-edge research team.

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