Institute Research Scientist Cell Biology Position
4 weeks ago
We are seeking a highly motivated and talented Research Scientist to join our Reverse Translation group at the MD Anderson Cancer Center. The successful candidate will be a key team member in the organization developing and independently leading research activities to advance projects from target validation through preclinical development to clinical proof-of-concept studies.
The Research Scientist will deploy state-of-the-art disease modeling, genetic and pharmacological approaches to integrate innovative biology with clinical research data to select and validate new target hypotheses, and position drug candidates for clinical success. By joining the TRACTION and the Therapeutics Discovery Division, you have the opportunity to use your talents to make a direct impact on the lives of our patients.
Key Responsibilities:- Independently lead and manage target and translational biology research activities on multiple discovery projects, delivering compelling validation packages and translational data to advance programs into clinical proof-of-concept trials in defined patient populations.
- Independently design, execute, analyze and interpret in vitro, ex vivo and in vivo experiments to validate novel therapeutic targets, inform on target mechanism of action, and explore translational hypotheses.
- Work closely with the data science team presenting and interpreting research findings to refine the experimental strategy.
- Deploy cutting-edge tools and technologies to develop in vitro and in vivo advanced cancer modeling, creation of somatic GEMM models, engineering of drug resistance mechanisms and unprecedented oncogenic drivers.
- Independently propose and lead innovative solutions to advance research projects.
- Deploy functional genomics (, CROP-Seq/Perturb-Seq) to enable novel target identification and deep functional characterization of relevant tumor contexts.
- Deploy cutting-edge epigenomic assays (, ChIP-seq, ATAC-seq, HiChIP-seq, single-cell technologies) to evaluate mechanisms of therapy resistance and tumor evolution.
- Proactively identify, evaluate and implement novel technologies to drive research discoveries and innovation.
- Apply knowledge of pharmacology and biomarker development to enable in vivo assessment of chemical matter and establish pharmacokinetic, pharmacodynamic, and efficacy relationships.
- Contribute to project team through lab-based activities.
- Contribute to developing strong collaborative relationships with internal and external groups.
- Interpret, present, and report research findings at internal meetings and external scientific conferences.
- Manage dedicated associate scientists towards project objectives.
- Master's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
- PhD, MD or equivalent degree in Biology, Cell Biology, Pharmacology or related field preferred.
- Six years' experience of relevant research experience in laboratory. With a PhD in a natural science or Medical degree, two years of required experience. With a Bachelor's, ten years of relevant research experience in laboratory.
- Relevant research and management experience beyond post-doctoral research maintaining hands-on experience. Industry R&D experience is preferred.
A collaborative attitude is essential for this position. The University of Texas MD Anderson Cancer Center is an equal employment opportunity employer.
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