Principal Research Scientist Medicinal Chemistry

3 days ago

Houston, Texas, United States MD Anderson Cancer Center Full time
Job Title: Principal Institute Research Scientist Medicinal Chemistry

This is a highly competitive position for a Principal Institute Research Scientist Medicinal Chemistry at MD Anderson Cancer Center. The successful candidate will lead cross-functional research to discover lead molecules for progression into novel oncology therapeutic agents that benefit patients.

Key Responsibilities:
  • Design, optimize, and synthesize small molecule targets from hits to leads.
  • Lead and manage junior scientists and project teams towards research goals.
  • Liaise with other members of the cross-functional project team to identify and optimize the next generation of cancer therapeutics.
  • Apply cutting-edge medicinal chemistry tools and methodologies to enable advancement of Institute projects.
  • Analyze data generated by various studies and leverage results for the design of future target molecules.
  • Collaborate with data scientists to triage high-throughput screening results and identify promising hits using cheminformatics techniques.
  • Apply chemistry-based data analytics software to identify early-SAR trends, track series progressibility, and design/optimize focused libraries.
  • Lead in the design and synthesis of small molecule modulators of protein targets through lab-based activities.
  • Lead in the hypothesis generation and design of new target molecules with improved overall profile.
  • Work closely with medicinal chemists, computational chemists, and other project team members in the design and optimization of compounds with improved potency, selectivity, and functional activity on their protein target, together with improved ADME properties.
  • Troubleshoot synthetic issues with their synthetic targets, as well as those of other project team members.
  • Manage patent filings in order to secure the intellectual property rights for novel small molecules.
  • Employ safe lab practices.
  • Maintain research records and laboratory notes.
Requirements:
  • PhD in one of the natural sciences or related field or Medical degree.
  • Five years experience of relevant research experience in lab.
  • Strong knowledge of contemporary synthetic organic chemistry, with a demonstrated track record of creative independent problem-solving.
  • Strong familiarity with the latest hit-finding techniques, including DNA-encoded libraries, fragment screening, and affinity-selection mass spectrometry methods.
  • Skilled experimentalist with demonstrated ability to conduct challenging multi-step organic chemistry synthesis and overcome synthetic hurdles.
  • Strong publication record in peer-reviewed journals.
  • Familiarity with automated and computational chemistry, including datamining software.
  • Experience mentoring and managing chemists and leading hit-to-lead exercises, as well as knowledge of the drug discovery process.
  • Excellent oral and written communication skills and organizational skills.
  • Familiarity with relevant biological disciplines and ability to integrate knowledge from these areas into the design of new bioactive compounds.
Working Conditions:

This position requires frequent exposure to hazardous chemicals and materials.

Physical Demands:

This position requires frequent standing, walking, and sitting, as well as occasional lifting, pushing, and pulling.

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