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Lead Scientist in Protein Production
2 months ago
DIRECT HIRE
Essential Qualifications:
- Experience with refolding E. coli proteins (Preferred)
- If lacking E. coli experience, must possess: expertise in recombinant proteins and familiarity with bispecific protein products
- Robust background in process development
- Experience in technology transfer - collaboration with CDMOs
- Proven communication and leadership skills. Previous management experience is essential, along with the ability to articulate management style.
Position Overview
We are in search of a seasoned leader in Protein Production and Process Development, with a focus on generating protein lead and Development Candidate molecules, ideally with experience in both mammalian and E. coli production methods. The Lead Scientist will coordinate a diverse team of research associates and scientists dedicated to the production of lead TCR bispecific molecules and the refinement of processes. The selected candidate and their team will operate in a dynamic, cross-functional environment to ensure smooth technology transfer to an external contract development and manufacturing organization (CDMO). Additionally, the incumbent will leverage Repertoires proprietary platform technologies to produce high-quality pMHC products through microbial or mammalian systems. The role will involve collaboration with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to supply protein reagents and leads, including comprehensive data packages to support Development Candidate nomination.
Key Responsibilities:
- Design and enhance upstream and downstream processes to produce lead and Development Candidate TCR bispecific molecules, facilitating effective technology transfer to contract manufacturing organizations.
- Deliver data packages, expertise, and guidance for TCR bispecific candidate nomination decisions.
- Transfer analytical methodologies to external CROs/CDMOs, providing additional training, troubleshooting, or technical support as required.
- Oversee the development and production of innovative pMHC reagents to support target identification, validation, and TCR affinity maturation for oncology and/or autoimmune applications.
- Foster team engagement, ownership, and agility to achieve ambitious outcomes.
- Draft and review technical documents and reports for inclusion in CMC sections of regulatory submissions.
Qualifications/Experience:
- PhD in Biochemistry, Biology, Bioengineering, Immunology, or a related field.
- Demonstrated experience in leading and managing laboratory teams within complex programs to achieve functional and corporate objectives.
- Minimum of 8+ years in the pharma/biotech sector with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and proteins produced in mammalian cells, overseeing both upstream and downstream process development.
- Experience in developing research strategies and managing operational outcomes through cross-functional and outsourced teams, along with budget planning and oversight.
- Proficient in technical report writing for regulatory submissions.
- Experience with bispecific protein products is advantageous.
- Ability to lead strategic discussions with senior management and external partners.
- Experience in fostering practical creativity within teams to adapt positively to changes.
- Proven ability to collaborate across teams to address challenges with strategic and operational implications for individuals, functions, and corporate performance.
