Protein Design and Informatics Investigator
3 weeks ago
We are seeking a highly skilled Investigator to join our Protein Design and Informatics team at GSK. As a key member of our team, you will be responsible for developing, integrating, and embedding advanced computational methods and predictive in silico models to accelerate the discovery of medicines.
As an Investigator in our team, you will work closely with data/ML scientists, cheminformaticians, bioinformaticians, and other experts to deliver impactful solutions that drive project progression. You will be responsible for generating, validating, and integrating sequence-/structure-based generative AIML models for the de novo design and multi-objective optimization of tool and therapeutic biologics.
You will also innovate, develop, and apply predictive models for protein design and developability engineering, utilizing large-scale NGS, patient-derived, and other proprietary in-house and external data sources. Additionally, you will identify and advocate for the opportunities afforded by scientific computation and platform automation and champion a "predict-first" culture by maximizing use of predictive technology in experimental lines.
Responsibilities- Develop and integrate advanced computational methods and predictive in silico models to accelerate medicines discovery
- Work with partner functions to generate, validate, and integrate sequence-/structure-based generative AIML models for biologics design
- Innovate and apply predictive models for protein design and developability engineering
- Identify and advocate for opportunities in scientific computation and platform automation
- PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields
- Experience in protein structural or sequence analysis
- Experience in one or more programming languages (e.g. Python, C/C++)
- Experience working across scientific and technical disciplines to deliver impactful solutions
- Experience developing or applying modern ML architectures for protein design models
- Experience predicting and analyzing protein-protein interactions and surfaces
- Experience analyzing antibody repertoires for sequence- and structure-based design
- Experience predicting structures of RNA or nucleic acid-protein complexes
- Experience with molecular simulation techniques
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We also offer a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Please visit our webpage Life at GSK | GSK to learn more about our company wide benefits and life at GSK.
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