Senior Scientist in Analytical Chemistry

2 weeks ago


Madison, Wisconsin, United States Arrowhead Pharmaceuticals Full time
Position Overview

Arrowhead Pharmaceuticals, Inc. is a pioneering biopharmaceutical organization dedicated to developing innovative therapies that target challenging diseases through gene silencing. Our advanced RNA interference (RNAi) technologies allow us to address genetic disorders by effectively silencing problematic genes, leading to significant advancements in treatment options.

About the Role

We are currently seeking a Senior Analytical Chemist to enhance our Discovery Analytical Chemistry team. The ideal candidate will be responsible for the creation and optimization of LC-MS analytical methodologies to support our ongoing research and development efforts focused on proteins and their conjugates.

Key Responsibilities

  • Formulate project and technical strategies within your area of expertise.
  • Utilize advanced scientific principles to tackle a diverse range of research challenges and devise innovative solutions for analytical issues related to drug discovery.
  • Design and conduct analytical studies that facilitate drug discovery and platform development across various therapeutic areas.
  • Independently initiate the development of new analytical methods while enhancing existing protocols.
  • Act as a project coordinator for both ongoing and new analytical method development initiatives.
  • Collaborate effectively with teams to address scientific and technical challenges.
  • Develop and validate analytical techniques to quantify and characterize pharmaceuticals and their impurities.
  • Perform sample analyses, interpret data/results, and integrate scientific findings to deepen understanding of drug properties and purification processes.
  • Represent the team by presenting research outcomes to cross-functional teams.
  • Identify and lead initiatives for improvement within the analytical processes.
  • Influence drug discovery and development directions through scientific insights.
  • Mentor and train junior scientists within the team.
  • Fulfill additional responsibilities as assigned.

Qualifications

  • PhD in analytical chemistry or a closely related field with a minimum of 2 years of relevant industry experience.
  • Extensive hands-on experience with LC-MS and HPLC for the characterization and quantification of proteins and protein conjugates.
  • Proficiency in sample preparation techniques, peptide mapping, MS/MS peptide sequencing, glycosylation analysis, disulfide bond mapping, and analysis of post-translational modifications.
  • Comprehensive understanding of protein chemistry and analytical methodologies.
  • Familiarity with routine maintenance of mass spectrometry equipment.
  • Strong troubleshooting and analytical problem-solving abilities.
  • Exceptional skills in data interpretation and integration.
  • Excellent communication and presentation capabilities.
  • Willingness to learn and adapt to new technologies.
  • Ability to prioritize tasks and adapt to a dynamic work environment.

Preferred Qualifications

  • Open-mindedness and eagerness to learn new technologies.
  • Experience with a variety of analytical techniques.

Arrowhead offers competitive compensation and a comprehensive benefits package.

All candidates must possess authorization to work in the United States.



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