Senior Scientist in Analytical Chemistry
2 weeks ago
Arrowhead Pharmaceuticals, Inc. is a pioneering biopharmaceutical organization dedicated to creating innovative therapies that target challenging diseases through gene silencing. Our advanced RNA interference (RNAi) technologies are at the forefront of medical science, enabling us to address a wide range of conditions by silencing specific genes responsible for disease progression.
Role Summary
We are currently seeking a Senior Analytical Chemist to enhance our Discovery Analytical Chemistry team. The ideal candidate will play a crucial role in developing LC-MS analytical methodologies to support our ongoing discovery and process development initiatives related to proteins and their conjugates.
Key Responsibilities
- Formulate project and technical strategies within your area of expertise.
- Utilize advanced scientific principles and concepts to tackle diverse research challenges, delivering innovative solutions for analytical issues in drug discovery and development.
- Design and implement analytical studies that facilitate drug discovery and platform advancements across various therapeutic areas.
- Independently create and refine analytical methods, enhancing existing protocols as necessary.
- Act as a project coordinator for both ongoing and new analytical method development efforts.
- Collaborate effectively with teams to address scientific and technical challenges.
- Develop and validate analytical methods for quantifying and characterizing drugs and impurities.
- Conduct sample analyses, interpret experimental data, and integrate scientific findings to enhance understanding of drug properties and synthesis routes.
- Represent the team in presenting research outcomes to cross-functional groups.
- Identify and lead initiatives for improvement within the analytical processes.
- Influence drug discovery and development strategies with scientific insights.
- Mentor and train junior scientists within the team.
- Perform additional duties as assigned.
Qualifications
- PhD in analytical chemistry or a closely related field, with a minimum of 2 years of relevant industry experience.
- Extensive hands-on experience with LC-MS and HPLC for the characterization and quantification of proteins and protein conjugates.
- Proficiency in sample preparation techniques, peptide mapping, MS/MS peptide sequencing, glycosylation analysis, disulfide bond mapping, and post-translational modification analysis.
- Comprehensive understanding of protein chemistry and analytical methodologies.
- Familiarity with routine maintenance of mass spectrometry equipment.
- Strong problem-solving and troubleshooting capabilities.
- Exceptional skills in data interpretation and integration.
- Excellent communication and presentation abilities.
- Willingness to learn and adapt to new technologies.
- Ability to prioritize tasks and respond to rapid changes in workload.
Preferred Qualifications
- A flexible mindset and eagerness to embrace new technologies.
- Experience with a diverse array of analytical techniques.
Arrowhead offers competitive compensation and a comprehensive benefits package.
All candidates must possess authorization to work in the United States.
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