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Principal Scientist/Director, Cancer Biology

2 months ago

San Francisco, California, United States General Proximity Full time
About General Proximity

We are a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

The Position

We are seeking an experienced cancer biologist to help lead our Biology Team. In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core drug discovery technology.

Responsibilities
  • Phenotypic assay development
  • Establishing pre-clinical in vitro/in vivo studies
  • Performing mechanistic studies on lead drug molecules
  • Spearheading forays into new oncology indications
  • Grant writing
About You

We are looking for candidates who possess high agency, initiative, independence, and self-accountability. Enthusiasm, intensity, and grit are also essential qualities for this role. Additionally, we value prosocial individuals who are passionate about creating life-saving medicines for patients in need.

Qualifications & Nice-To-Haves
  • PhD in Cancer Biology, Cell Biology, or related field
  • 5-7+ years of industry experience
  • Deep understanding of small-molecule drug discovery and its relationship to human disease
  • Strong experience with:
    • Mechanistic studies of cancer cell signaling and PTM analysis
    • Phenotypic assay development for cancer drug discovery (low to high throughput)
    • Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, MOA studies)
    • Excellent cellular and molecular biology knowledge/experience (cancer cell lines, generation of stable cell lines using lenti/CRISPR systems, IP/pull down assays, RNA-Seq, flow cytometry, plasmid design)
    • Top-notch written and oral communication skills
  • Proficiency in:
    • Managing a team of exceptional scientists and research associates
    • Target/indication selection
    • Pre-clinical and IND-enabling studies
    • Animal models of cancer (GEMM, orthotopic, xenograft models)
    • Managing CROs for in vivo studies
    • Grant writing
  • Nice to have:
    • Prior experience on teams that have successfully advanced research to the clinic
    • Familiarity or experience with PROTAC/next-gen IPM technologies
    • Experience with PPI techniques, e.g., BRET, APEX/BioID, AlphaScreen
Benefits
  • Strong equity incentives
  • Top-tier medical, dental, and vision coverage + One Medical membership
  • 401(k) retirement plans
  • Education and health/fitness incentive programs
  • Meditation retreats
  • Reading budget
  • Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer