Research Scientist

4 weeks ago


Atlanta, United States Spelman College Full time

Scientist (contract), in vitro assay development, Biochemical and Cellular Pharmacology Department, gRED. We are seeking a creative and independent Research Scientist to join our team in Department of Biochemical and Cellular Pharmacology within Genentech’s Research and Early Development (gRED) organization. This is an exciting opportunity to develop in vitro models for screening of novel modalities in complex cell-based systems. The successful candidate will support quantitative assay development and mechanism of action (MOA) studies for functional characterization of targets and in vitro screening of novel therapeutic modalities. This individual will focus on developing and validating functional assays for miniaturization and high-throughput screening. In addition, the candidate will function as part of a multi-disciplinary project teams. This is a fantastic opportunity to join a dynamic team, work on transformative science, and help building exciting physiologically relevant human cell models for drug discovery. Responsibilities: Contribute to the design and execution of in vitro studies for development of screening assays. Develop, perform, and optimize in vitro biochemical and cellular assays to evaluate novel modalities in complex cell culture models. Support development of robust in-house capabilities to perform in vitro experiments with higher throughput formats. Collaborate cross-functionally with chemistry, biology and protein sciences teams. Manage cell line procurement, optimal culture conditions, expansion, storage, and inventory Participate in project teams, contribute to interpretation and communication of the data. Requirements and Experience: M.S. with major in biology, biochemistry, cell biology, molecular biology, or related fields. Exceptional B.S. candidates with 2-5 years of relevant experience in academia, biotechnology or pharmaceutical industry are welcome. Strong experience in design and execution of in vitro experiments using cell culture, cell viability assays, Western blot analysis, qPCR, ELISA, cell-based fluorescence and chemiluminescence assays, and cell line engineering. Hands-on experience in primer design, cloning, nucleic acid (DNA/RNA) extraction and characterization methods is desirable. Familiarity with quantitative biochemical binding assays using UV-Vis spectrometry, fluorescence spectrometry, luminescence methods and use of plate readers for multiplex assays. Contribute to experimental design, literature review, and execution of assay development initiatives. Analyze and interpret experimental results and design experiments to optimize assay development. Highly organized, diligent, and quality focused with detailed knowledge of Excel, Word, PowerPoint, GraphPad Prism, FlowJo, Spotfire is desirable. Creativity and problem-solving skills paired with ability to excel in a highly collaborative environment. Excellent oral and written communication and interpersonal skills Use electronic lab notebook and automation workflows for documentation. #J-18808-Ljbffr



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