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Research Associate

4 months ago

Wilmington, United States Prelude Therapeutics Full time
Prelude is seeking an experienced and highly motivated Research Associate with a background in quantitative bioanalysis by LC-MS. This individual will be responsible for the conduct of early ADME screening assays such as microsomal stability and protein binding, development and/or qualification of sensitive LC-MS/MS methods, and bioanalysis of pharmacokinetic studies for our small molecule candidates. To be considered for this position, the candidate must have a BS in analytical chemistry or equivalent discipline with 2 or more years of experience with quantitative bioanalytical methods development. Experience with sample preparation using liquid/liquid extraction, protein precipitation, and solid phase extraction; HPLC separations; and LC-MS and triple quadrupole LC-MS/MS equipment, computerized data acquisition, and integrated automation systems are preferred. This position will interact primarily with discovery groups, however, collaboration with the development scientists in both GLP and non-GLP environments may be required. Excellent oral and written communication skills are required. Prelude offers a vibrant and collegial work environment and excellent career growth opportunities. Prelude is ideally located within 25 minutes from the Philadelphia International Airport at the Delaware Innovation Space, an emerging research campus in the DuPont Experimental Station.

Responsibilities

• Conduct routine ADME assays in support of discovery programs

• Assist in development/validation of new assay systems

• Independently develop, qualify and troubleshoot LC-MS methods for the determination of our molecules from in vitro and non-clinical pharmacokinetic studies

• Assist in coordination of outsourced research studies.

• Work independently and in a team environment and balance the demands of multiple tasks.

• Keep concise and accurate records of all study activities

• Follow all safety protocols and ensure a safe work environment

• Complete tasks as assigned by management.

Requirements

• BS degree in chemistry, biochemistry or related field with 2+ years' experience

• Experience in the conduct of routine in-vitro screening assays (protein binding, microsomal stability, ec)

• Quantitative LC-MS bioanalytical experience

• Experience with ABSciex mass spectrometers and Analyst software preferred

• Good communication skills for rapid and concise delivery of results to internal program teams and key decision makers

• Experience with ELN, ChemDraw, Prism, Microsoft word/excel/powerpoint, Phoenix WNL