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Post-Doctoral Research Fellow- Cancer Biology- Lab of Dr. Andrew South
4 months ago
Squamous cell carcinomas (SCC) collectively are the most common ectodermal cancers, resulting in >300,000 deaths per year. SCCs arise from renewable squamous epithelial cells that serve to create a barrier to the external environment in the skin, esophagus, lung and cervix. An early feature of squamous neoplasia is disruption of programmed differentiation, typically associated with thickening of the epithelium and increased proliferation. My laboratory focuses primarily on cutaneous SCC (cSCC) which is the most frequent skin cancer with malignant potential and contributes to greater than 1 in 4 skin cancer deaths in Caucasian populations. Patient groups with a high propensity to develop these tumors face a significant risk of mortality. One such group is the genetic skin blistering condition recessive dystrophic epidermolysis bullosa (RDEB) which is a devastating disease caused by mutations in a single gene, COL7A1 . COL7A1 encodes for a protein called type VII collagen that forms connective fibrils linking the outer layer of the skin to the underlying tissue. My laboratory has a long standing interesting in trying to understand why mutations in this single gene lead to frequent and multiple life-threatening skin cancers.
PRIMARY FUNCTION :
To use their training in structural biology, biochemistry and molecular biology to design and execute experiments related to an NIH-sponsored research project in the lab.
ESSENTIAL FUNCTIONS:
- Collects and assembles data for any type of oral or written presentation.
- Independently develops scientific hypotheses related to ongoing work in the laboratory.
- Independently designs experiments to test hypotheses.
- Independently carries out or delegates procedures for experiments.
- Analyzes results of experiments independently.
- Independently prepares oral and written reports for the P.I. on research to include, but not limited to: coherently and effectively communicating our laboratory research by writing abstracts, manuscripts, grant proposals and data reports for grants and oral presentations with corresponding slide presentation for PI, local and national meetings.
- Performs routine and more difficult procedures, analyzes data and coherently presents results in the form of presentations, abstracts, manuscripts and the basis for grant writing, preparation and submission.
- Interacts with co-workers, visitors, and other staff consistent with the iSCORE values of Jefferson.
Qualifications
EDUCATIONAL/TRAINING REQUIREMENTS :
Ph.D., in structural biology and molecular biology
EXPERIENCE REQUIREMENTS :
Previous experience in an academic lab setting preferred.
Closing Statement
Jefferson includes Thomas Jefferson University and Jefferson Health, a dynamic university and health system with broad reach across the Delaware Valley. Jefferson is the second largest employer in Philadelphia and the largest health system in Philadelphia based on total licensed beds.
Through the merger of Thomas Jefferson University and Philadelphia University in 2017, our University includes ten colleges and four schools. We are an NCAA Division II university and an R2 national doctoral university offering undergraduate and graduate-level programs that provide students with a forward-thinking education in architecture, business, design, engineering, fashion and textiles, health, medicine and social science.
Jefferson Health, the clinical arm of Thomas Jefferson University, has grown from a three-hospital academic health center in 2015, to an 18-hospital health system through mergers and combinations that include hospitals at Abington Health, Aria Health, Kennedy Health, Magee Rehabilitation and Einstein Healthcare Network. We have over 50 outpatient and urgent care centers; ten Magnet®-designated hospitals (recognized by the ANCC for nursing excellence); the NCI-designated Sidney Kimmel Cancer Center (one of only 70 in the country and one of only two in the region); and one of the largest faculty-based telehealth networks in the country. In 2021, Jefferson Health became the sole owner of HealthPartners Plan, a not-for-profit health maintenance organization in Southeastern Pennsylvania. We are the first health system regionally to create an aligned payer-provider partnership.
Jefferson's mission, vision and values create an organization that attracts the best and the brightest students, faculty, staff, and healthcare professionals, as well as the most visionary leaders to drive exceptional results.
- OUR MISSION: We improve lives.
- OUR VISION: Reimagining health, education and discovery to create unparalleled value
- OUR VALUES: Put People First, Be Bold & Think Differently and Do the Right Thing
As an employer, Jefferson maintains a commitment to provide equal access to employment. Jefferson values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans.
