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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Principal Scientist, Protein Production
4 weeks ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
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Principal Scientist, Protein Production
3 months ago
Cambridge, United States Repertoire Immune Medicines Full timeJob DescriptionJob DescriptionPrincipal Scientist, Protein Production and Process DevelopmentCompany OverviewRepertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the...
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Principal Scientist, Protein Production
3 months ago
Cambridge, United States Repertoire Immune Medicines Full timeJob DescriptionJob DescriptionPrincipal Scientist, Protein Production and Process DevelopmentCompany OverviewRepertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the...
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Principal Scientist, Protein Production
4 weeks ago
Cambridge, United States Planet Pharma Full timeDIRECT HIREPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must have: experience w/ Recombinant protein and experience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must have previous management experience and...
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Principal Scientist, Protein Production
1 month ago
Cambridge, United States Planet Pharma Full timeDIRECT HIREPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must have: experience w/ Recombinant protein and experience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must have previous management experience and...
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Senior/Principal Scientist
1 month ago
Cambridge, United States Pearl Bio Full timeAbout Pearl: Pearl Bio, Inc. is a biotech startup based in Cambridge, MA. Built upon 15+ years of research at the labs of Prof. Farren Isaacs (Yale) and Prof. Michael Jewett (Stanford/Northwestern), Pearl’s platform combines synthetic biology, genomically recoded organisms, and ribosomal engineering to genetically encode chemistries into novel medicines...
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Lead Scientist in Protein Production
5 days ago
Cambridge, Massachusetts, United States Planet Pharma Full timeDIRECT HIRE Essential Qualifications: Experience with refolding E. coli proteins (Preferred) If lacking E. coli experience, must possess: expertise in recombinant proteins and familiarity with bispecific protein products Robust background in process development Experience in technology transfer - collaboration with CDMOs Proven communication and leadership...
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Principal Scientist
2 weeks ago
Cambridge, United States Planet Pharma Full timePrincipal ScientistLocation: Cambridge, MASalary: $160-180K + equity Open to relocation within the Northeast.Required Skills: Expertise in downstream processing.Experience with microbial and mammalian systems.Experience in refolding E. coli proteins is highly desirable.If E. coli experience is not available, candidates must have experience with recombinant...
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Principal Scientist
2 weeks ago
Cambridge, United States Planet Pharma Full timePrincipal ScientistLocation: Cambridge, MASalary: $160-180K + equity Open to relocation within the Northeast.Required Skills: Expertise in downstream processing.Experience with microbial and mammalian systems.Experience in refolding E. coli proteins is highly desirable.If E. coli experience is not available, candidates must have experience with recombinant...
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Principal Scientist
10 hours ago
Cambridge, United States Planet Pharma Full timePrincipal Scientist, Protein Production & Process DevelopmentPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must haveExperience w/ Recombinant proteinExperience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must...
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Principal Scientist
4 weeks ago
Cambridge, United States Planet Pharma Full timePrincipal Scientist, Protein Production & Process DevelopmentPriority Must Haves:Refolded E. coli experience (Ideal)If no E. Coli experience, must haveExperience w/ Recombinant proteinExperience with bispecific protein productsStrong process development backgroundTech Transfer experience - working with CDMOStrong Communication and Leadership experience. Must...
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Lead Protein Scientist
5 days ago
Cambridge, Massachusetts, United States Bristol-Myers Squibb Full timeJoin Our TeamAt Bristol Myers Squibb, we offer a unique opportunity to engage in work that is both challenging and rewarding. Our environment fosters innovation and collaboration, allowing you to contribute to groundbreaking advancements in biopharmaceuticals. You will be part of a diverse team that is dedicated to transforming the lives of patients through...
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Associate Scientist
3 weeks ago
Cambridge, United States Pioneer Data Systems Inc Full timeOur client, a world-leading Pharmaceutical Company in Cambridge, MA is currently looking for a Associate Scientist to join their expanding team. Position Details: Job Title: Associate Scientist / Protein Purification Duration: 18 months contract, extendable up to 36 monthsLocation: Cambridge, MA Note: The client has the right-to-hire you as a permanent...
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Lead Scientist in Protein Engineering
5 days ago
Cambridge, Massachusetts, United States Planet Pharma Full timePosition Overview:We are looking for a highly skilled and experienced Senior Scientist specializing in Protein Production and Process Development. The ideal candidate will have a robust background in producing protein lead and Development Candidate molecules, with a focus on both mammalian and E. coli production methodologies.Essential...
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Lead Scientist in Protein Engineering
5 days ago
Cambridge, Massachusetts, United States Pearl Bio Full timeAbout Pearl Bio: Pearl Bio, Inc. is an innovative biotech startup focused on advancing the frontiers of synthetic biology and genome engineering. Our foundation is built on over 15 years of pioneering research, aiming to develop groundbreaking medicines and materials through the integration of synthetic biology and advanced engineering techniques. Position...
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Associate Scientist, Protein Sciences
2 months ago
Cambridge, Massachusetts, United States Flagship Pioneering Full timeCompany Summary:Founded by Flagship Pioneering in 2021, Metaphore aims to unlock breakthroughs that outperform today's drugs for maximum patient impact, We adapted this idea to drug discovery. MIMICTM, our computationally driven bioplatform that couples machine learning with molecular mimicry, engineers therapeutics to trigger a desired biological response....
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Cambridge, United States Repertoire Immune Medicines Full timeJob DescriptionJob DescriptionSenior Scientist, Protein Engineering and Molecular SciencesCompany Overview Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the belief...
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Scientist II/Senior Scientist, Protein Engineering
2 months ago
Cambridge, United States Repertoire Immune Medicines Full timeJob DescriptionJob DescriptionSenior Scientist, Protein Engineering and Molecular SciencesCompany Overview Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the belief...
Principal Scientist, Protein Production
2 months ago
Company Overview
Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODETM platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.
From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire’s team is creating a new pipeline of therapeutic immune medicines enabled from its DECODE discovery platform. Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with autoimmune diseases such as type 1 diabetes and multiple sclerosis, creating programmable tolerizing mRNA vaccines to restore immune homeostasis in these indications. In oncology, Repertoire’s decoding of tumor-infiltrating lymphocytes and the antigens they target is enabling development of TCR bispecific therapies and mRNA cancer vaccines to treat solid tumors.
Role Overview
We are seeking an experienced Protein Production and Process Development leader with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes. The selected candidate and his/her/their team will work in a highly dynamic and cross-functional environment to facilitate seamless technology transfer to an external contract development and manufacturing organization (CDMO). The incumbent will also enable Repertoire’s proprietary platform technologies with high quality pMHC products produced by microbial or mammalian systems. The incumbent will interface with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to provide protein reagents and protein leads, including data packages supporting Development Candidate nomination.
Key ResponsibilitiesDevelop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
Drive team engagement, ownership, and agility to deliver ambitious results.
Author and review technical documents and reports for inclusion in CMC sections of regulatory filings. Qualifications/Experience
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years’ experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Experience in research strategy development and operational management of research outcomes through cross-functional and outsourced teams, as well as budget planning and management.
- Technical report writing for inclusion in regulatory submissions.
- Desirable to have experience with bispecific protein products.
- Ability to drive strategic discussions with senior level management and external partners.
- Experience in building practical creativity in teams to persist and respond positively to changes.
- Experience in collaborating across teams to resolve problems with strategic and operational impact on individual, function, and corporate performance.
Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.
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