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Senior Scientist, LNP Formulation and Delivery Technology
3 months ago
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
The Delivery and Editing Technologies Team optimizes current and new editing and delivery technology formats to provide the best in vivo delivery and gene editing solutions for current and future therapeutic programs and is looking to add highly talented and motivated candidate to help develop our lipid nanoparticle (LNP) platform for advancing new therapies. This individual will lead the development of the lipid nanoparticle (LNP) formulation process and produce LNP-encapsulated gene editing agents to support company’s in vitro and in vivo pre-clinical studies. In addition, they will support the characterization assays for LNP batches and show a passion for developing delivery strategies suitable for clinical investigation. With a strong background in LNP formulation and characterization this person will work within cross-functional product development teams including Formulation Development, mRNA Process Development, Analytical Development, Engineering and Quality in development and commercialization of gene therapy drug products.
Key Responsibilities:
As the Senior Scientist, LNP Formulation and Delivery Technology, you will be responsible for:
- Develop and optimize the LNP formulations, including the potential inclusion of targeting moieties, to support pre-clinical in vivo delivery animal studies
- Formulate mRNAs, guide RNAs, and other nucleic acid modalities to support company’s in vitro and in vivo pre-clinical studies
- Characterization of LNPs to support transition to process development groups
- Play an important role in equipment design for scale up LNPs-mRNA production to required scales, for both pre-clinical and clinical development
- Coordinate with the chemistry group at the Boulder site to ensure smooth technology transfer between our chemistry and in vivo teams
- Successfully manage direct reports to achieve company LNP goals
- Maintain a detailed electronic lab notebook and documentation records
Requirements
Required Qualifications:
The ideal candidate will possess:
- Ph.D. in Chemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences or related discipline or B.S./M.S. with 7-10 years industry experience
- Industry Experience Required
- Strong knowledge of nucleic acid chemistry, development of liposomal, LNPs, or similar lipid-based drug products
- Experience with the in vitro and in vivo experiments and assays used for screening candidate formulations
- Knowledge of process scale up/scale down for liposomal, LNPs, or similar lipid-based drug products is a major plus
- Knowledge of GMP and GLP regulations is a plus
- Highly organized and detail-oriented
Benefits
Benefits Summary:
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.
Fostering Belonging. Fueling Innovation. Transforming Lives.
