SENIOR PRINCIPAL RESEARCH SCIENTIST, IMMUNOLOGY COMPUTATIONAL BIOLOGY FIBROSIS LEAD

3 weeks ago

Cambridge MA USA, United States AbbVie, Inc Full time
Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Genomics Research Center (GRC) Immunology Computational Biology group at AbbVie is seeking a highly motivated, experienced computational biology leader to play an integral role in a multi-disciplinary team focused on developing new therapies for the treatment and cure of immunological diseases. AbbVie's GRC is a center of excellence for bioinformatics, functional genomics, human genetics and pharmacogenomics. GRC works across all R&D including discovery and clinical development, and multiple areas such as process sciences, search and evaluation and corporate strategy.

This position will be based in Cambridge, Massachusetts. The candidate will lead a team focused on fibrotic diseases and work closely with computational biologists across the network and be embedded in research project teams in immunology discovery and precision medicine to analyze multi-omic datasets to derive insights into immunological diseases, identify novel therapeutic targets and biomarkers specific to patient cohorts and AbbVie pipeline drugs. The successful applicant will address key project team questions related to forward and reverse translation, genomic biomarker identification and mechanistic characterization, and communicate findings to internal and external stakeholders . In addition, the candidate will contribute to presentations at scientific conferences and publications of translational findings in peer reviewed journals, new drug applications and regulatory filings.

Key Responsibilities:

* Partner with immunology discovery and precision medicine to perform hands on omics data analysis to address key project questions related to forward/reverse translation, genomic biomarker development and mechanistic characterization
* Be our fibrotic disease area representative in program teams and coordinate cross-functional projects
* Provide expert guidance and suggestions on experimental design and analytical insights
* Perform novel target identification from internal and external omics data, and advance these targets into the immunology pipeline
* Support target and biomarker development for enterprise-critical late-stage programs experimental medicine and clinical trials
* Evaluate patient stratification hypothesis for immunological diseases and integrate with clinical trial data to predict personalized treatments
* Develop and implement analytical approaches and best practices for novel technologies such as spatial transcriptomics, single cell sequencing and CRISPR
* Hire, mentor and develop scientists with high caliber and potentialSignificant Work Activities -Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

Qualifications

BASIC QUALIFICATIONS:

* PhD. degree in bioinformatics, statistics, mathematics, computer science, computational biology, genomics or a related field with a minimum of 8 years of experience in industry or academia.
* Master's degree with typically 12 years of experience
* At least 2 years of experience managing direct reports
* A minimum of 5 years of hands-on experience in analyzing multi-omics data (e.g. bulk and single-cell RNA-seq, proteomics, genetics, epigenetics data)
* Highly proficiency in machine learning and algorithmic analysis of multi-omics data
* Highly proficient with statistical and programing languages (R, Python), Unix/Linux/cloud environment, and SQL and noSQL database query languages

Preferred:

* Deep understanding of autoimmune diseases especially fibrotic disease biology
* Expertise in computational biology and biomarker strategies
* Expertise in predictive modeling, quantitative data analysis, and machine learning
* Experience with multi-omics data integration and with novel technologies such as spatial transcriptomics, Perturb-seq, CRISPR, etc.
* Experience with establishing team goals and strategies, managing objectives and priorities for their direct reports, and mentor and develop junior scientists in both team and matrixed environment
* Proactive scientific leader with outstanding presentation and communication skills that foster collaboration and teamwork
* A collaborative and self-motivated individual with a strong work ethic, ability to work in a dynamic environment and able to manage multiple objectives in parallel and adapt to changing priorities

Additional Information

Applicable only to applicants

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