Principal Scientist or Assoc. Dir. of T cell in vivo Pharmacology
2 weeks ago
Adaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.
Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.
Primary Responsibility
Join Adaptimmune, a pioneering adoptive T cell therapy (ACT) company dedicated to curing cancer. As a leader in the field, we are advancing multiple clinical stage engineered T cell receptor-T (TCR-T) candidates, including the groundbreaking Afami-cel for Sarcoma. We are seeking an in vivo Pharmacology Principal Scientist/Associate Director to join our Preclinical Efficacy and Safety group to contribute to advancing Adaptimmune's early preclinical pipeline toward clinical evaluation. You will deploy your subject matter expertise in cancer immune oncology and ex vivo/in vivo pharmacology to lead the development and execution of fit-for-purpose xenogeneic, syngeneic and/or humanized mouse models to support mechanism-of-action, proof-of-concept, and IND-enabling studies. Further, you will be an ad hoc contributing collaborator to our in vitro immunology team and responsible as operational lead to oversee our on-site vivarium, share accountability for updating and maintaining our IACUC protocol, and be responsible for ensuring proper training of in vivo staff. Additional responsibilities include regularly preparing and reviewing study reports, manuscripts and publications, and research presentations for internal stakeholders and external conferences. Though based in Kendall Square, you will collaborate closely and extensively with both US and UK Immunology and Preclinical Research Teams. This role suits collaborative, action-oriented in vivo immunologists seeking career growth.
Key Responsibilities
* Establish and develop syngeneic and/or humanized mouse models to test Pipeline and Preclinical candidates, collaborating with UK and US stakeholders to select appropriate models.
* Lead and conduct in vivo and ex vivo pharmacology studies supporting candidate selection, mechanism-of-action, and IND-enabling studies for Pipeline and Preclinical Research.
* Develop, evaluate and validate in vivo tumor models, PK/PD methods, and ex vivo immunoprofiling studies.
* Offer expert guidance and hands-on support to in vitro immunology studies.
* Collaborate cross-functionally as in vivo lead representative on preclinical project teams.
* Author study protocols and reports, prepare documents (e.g., IND reports) oversee data analysis, and assimilate data packages for clear communication to internal stakeholders or external presentation/publication.
* Manage Vivarium operations, ensuring compliance with IACUC protocols and adherence to animal use and care guidelines, policies, and regulations.
Qualifications & Experience
Required
* PhD in a biology discipline with 5+ years post-PhD experience (2+ years in industry) with in vivo studies of cell therapies and/or cancer immunotherapies (e.g, CAR-T).
* Experienced in the development, technical execution, and validation of xenogeneic and syngeneic and/or humanized mouse tumor (solid and hematologic) model studies.
* Extensive experience in preclinical in vivo evaluation of T cell therapies with coupled expertise in ex vivo T-cell pharmacokinetic and pharmacodynamic readouts such as T-cell persistence, immunophenotype, biodistribution (by flow cytometry and IHC), cytokine release
* Firsthand expertise in ex vivo immunoprofiling using ELISA and flow cytometry, with high favourability toward experience with adoptive T cells.
* Highly practiced in mouse handling, including drug administration (e.g., by IP, IV, SQ) blood collection, surgical dissection, and euthanasia in accordance with animal care guidelines.
* Demonstrated commitment to quality, excellent attention to detail, experience managing in vivo electronic databases and records; experienced user of electronic laboratory notebooks
* Demonstrated track record of working collaboratively and overcoming challenges.
Desirable
* Subject expertise in in vivo evaluation of T cell therapeutics (CAR-T, TCR-T, TRuC, or BiTEs)
* Strong understanding of T cell biology, tumor immune microenvironment.
* Experience in executing and authoring IND-enabling preclinical in vivo studies and reports.
* Experience with managing CROs
At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.
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