Senior Research Associate, Biology

2 weeks ago

Cambridge, United States Delphia Therapeutics Full time

About Us:

Delphia is igniting a new field of therapeutics in hopes to transform the care of cancer patients. Together, we are working to advance first-in-class targeted cancer medicines leveraging Activation Lethality, a new field of cancer biology centered on cancer’s surprising vulnerability to oncogene overactivation. While a bold idea, activation lethality is grounded in cancer genetics, and our medicines have potential to deliver benefit as monotherapy and to complement existing oncogene inhibitors to more durably hold cancer in check. Partnering together in a supportive, open, and collaborative environment, we share a sense of purpose, urgency, and commitment to patients to approach cancer biology through a different perspective and to establish activation lethality as the next wave of oncology therapeutics.


The Difference You’ll Make

Delphia is searching for a Senior Research Associate, Biology to join the team This scientist will play a critical role in design and execution of cell-based studies to advance our activation lethality medicines from target validation through drug discovery to the clinic. They will carry out a range of studies spanning a variety of molecular and cellular techniques. As an integral member of project teams, they will share plans, results and conclusions with a fast-moving interdisciplinary scientific team & contribute to a mission-driven culture dedicated to advancing important new medicines to patients.


What You’ll Do:

  • Design and execute cell-based studies to support identification & validation of novel targets as well as the advancement of drug discovery projects from hit discovery through IND.
  • Employ a wide variety of laboratory techniques including mammalian cell culture, Western blotting, CRISPR, RNAi, phenotypic assays, flow cytometry, etc
  • Independently design and execute cell-based experiments & share results in a variety of settings
  • Analyze experimental results, brainstorm and troubleshoot findings thoughtfully and proactively
  • Join a fast-paced culture where self-motivation, learning agility, rigor & attention to detail are complemented with highly cohesive and collaborative teamwork and communication
  • Challenge yourself and the organization to continually innovate in laboratory practices and techniques
  • May manage CRO biologists to efficient and high-quality delivery of key experimental results for drug discovery


What you bring:

  • Background in cancer biology; experience and demonstrated success using cell biology techniques to advance oncology projects
  • Strong technical skills in mammalian cell culture are required; proficiency with core laboratory techniques such as Western blotting, CRISPR, RNAi, phenotypic assays are also essential
  • Excellent organizational, communication, multi-tasking & teaming skills
  • Outstanding problem-solver; innovative, creative, and versatile in approach to problems and their solutions
  • Bold-but-grounded: ambitious and innovative in pursuit of emerging science for new medicines, yet capable to ground innovation with practical experience
  • BA/MA in Biology or related discipline, with 3-5+ years of industrial experience, or equivalent

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