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Manufacturing Engineer

2 months ago

Redwood City, United States Discover International Full time

Biotech company in Redwood City, CA is currently looking for a Pilot Plant Associate for their Downstream team. Bellow the Activities this person will be in charge of:


Responsibilities:

  • Perform pilot scale downstream purification process and manufacturing (post cell lysate to final formulation) by utilizing column chromatography, CsCl, UFDF, and various filtration steps.
  • Follow good documentation practices to maintain accurate records.
  • Work closely with team members to perform buffer preparation.
  • Set-up, operate and maintain required downstream laboratory equipment.
  • Maintain reagent, sample, and consumables inventory.
  • Assist with data entry and data analysis in Excel and/or other statistical programs.
  • Work closely with the downstream team to perform downstream experiments.
  • Ensure safe workplace in compliance with the company and EHS' rules and regulations.
  • Work with Assay Development and Quality Control to coordinate testing.
  • Work to identify optimize, revise, and update current process batch records, protocols, and procedures to make them more robust and streamlined.


About you:

  • Requires a Bachelor’s degree (or higher) in chemical/biochemical engineering or related fields with 4+ years of downstream purification experience.
  • Proficient in general and non-routine laboratory skills including aseptic technique, multi-channel pipetting and biosafety cabinet operations.
  • Hands on experience with buffer preparations, TFF (Hollow Fiber/Cassettes), UF/DF and Column Chromatography Purification. Experience working with AKTA Avant is required.
  • Requires some knowledge of GxP standards, and the ability to apply compliance principles to laboratory practices.
  • Able to work in a fast-paced environment as a team player with effective communication skills.
  • Excellent computer skills; especially proficient in Excel and Word.
  • Strong desire to learn new technologies, skill sets, and the science behind AAV processing.
  • Strong teamwork and communication skills.
  • Some overtime required, as needed.