Scientist II, Chemistry
1 month ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description
AbbVie Process Chemistry is responsible for inventing and characterizing chemical processes and supporting the preparation of drug substances to enable toxicology studies, clinical trials, and drug product development for AbbVies pre-clinical and clinical candidates. We contribute to the development of innovative chemistry solutions and new process technology, resulting in the development of safe, sustainable, and cost-effective manufacturing processes. We are seeking a highly motivated scientist with experience in process chemistry and/or the development of antibody-drug conjugate drug substances.
The successful candidate will contribute to the development of conjugation chemistry processes in the lab and participate on project teams to support projects from pre-clinical stages through our clinical studies. Project teams interactions will include productive collaboration and strong communications with allied functions across analytical, engineering, small molecule drug linker synthesis, regulatory, quality and manufacturing.
Key Responsibilities:
Responsible for developing and characterizing antibody-drug conjugate (and other modalities) processes in the laboratory and translating them to scalable processes, with direction from or interaction with supervisor.The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, drug product development, and program management.Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise.Proactively seek out new information in the literature and demonstrate application on individual project(s) as well as the overall program.May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.Understand and adhere to corporate standards regarding code of conduct, safety, and GxP compliance.Qualifications
MS degree in chemistry with 2+ years of laboratory experience or BS degree in chemistry with 5+ years laboratory experience.A broad range of functional expertise in modern synthetic organic chemistry, compound purification, spectral analysis and interpretation.An ability to search the chemical literature and evaluate potential solutions to synthetic problems.Strong written and verbal communication skills.Experience performing process development, new reaction characterization and study of reaction mechanism.Experience in antibody-drug conjugate process development is beneficial.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this postingbased on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more orless than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of payis a considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission,incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paidandmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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