Scientist, RNA Technology

2 months ago


Boston, Massachusetts, United States Verve Therapeutics Full time
The Company

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.


The Position

We are seeking a Scientist, RNA Technology to join a team focused on design and optimization of RNA for Verve's novel CRISPR gene editing therapies. The ideal candidate will have experience with nucleic acid technology, biochemistry, molecular biology, and chemical modification of oligonucleotides. Candidates will also have a desire to apply creative problem-solving skills to improve the potency, stability, and safety of RNA constructs with emphasis on implementing product improvements that are suitable for clinical development. You will mentor junior members of the team in planning and conducting experiments. In this highly cross-functional role, you will perform a wide range of lab experiments as well as coordinate evaluation activities across different functional areas throughout Verve R&D and Technical Operations

Job Responsibilities

  • Apply creative thinking and well-designed experimentation to establish a science-based understanding of RNA technology and design.
  • Participate in and lead specific areas of design and production of new gene editing RNA constructs to improve efficacy, safety, and stability.
  • Coordinate with cross-functional process development, analytical development, gene editing, and preclinical teams to perform matrixed evaluations of RNA constructs.
  • Use tissue culture to evaluate the efficacy of novel RNA designs and process improvements.
  • Select and coordinate contract research organizations to perform external projects as needed.
  • Mentor more junior members of the team in designing and conducting experiments.
  • Act as a subject matter expert and reference point in RNA design, both within the team and in cross-functional discussions. Maintain a current understanding of the relevant primary literature.
  • Collect, organize, and analyze data, interpret results, write protocols, and summarize work in presentations and technical reports.

Qualifications

  • Ph.D. in biochemistry, biophysics, biological sciences, chemistry, or biomedical/chemical engineering OR
  • M.S. in biochemistry, biophysics, biological sciences, chemistry, or biomedical/chemical engineering with 4-7 years of drug development experience
  • Knowledge of RNA synthesis, biochemistry, and biophysics is preferred.
  • Proficient in conducting laboratory research and experienced with techniques such as molecular cloning, cellular transfection, enzymatic assays, HPLC, FPLC, RNA synthesis, purification, capillary electrophoresis, spectroscopy, ELISA, and western blot.
  • Proven ability to plan and execute experiments and analyze data independently.
  • Attention to detail, critical analysis of data and troubleshooting abilities.
  • Good writing and communication skills; ability to understand and communicate scientific information.

Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.



  • Boston, Massachusetts, United States Joulé Full time

    Position: Research Scientist in Immunology Location: Boston, MA areaEmployment Type: Direct HireWork Schedule: Monday to Friday; 9am-5pm (with some flexibility)Qualifications: PhD in Biology or Immunology, with a focus on innate immunityExperience Requirements: 12 years of experience is advantageous, but not mandatory. Candidates with limited practical...


  • Boston, Massachusetts, United States NextRNA Therapeutics Full time

    As a Biochemistry Scientist II / Senior Researcher at NextRNA Therapeutics, you will be part of a dynamic and innovative team dedicated to enhancing patient outcomes through advanced RNA-targeted therapies. Your role will be pivotal in merging biochemical methodologies with our drug development initiatives. About You:You possess a wealth of experience in...

  • Scientist I

    4 weeks ago


    Boston, Massachusetts, United States Harvard University Full time

    Harvard UniversityPosition Title: Scientist I - Bone Marrow Chips in SpaceReq ID: 66588BRSchool or Unit: Wyss Institute at Harvard UniversityDescription: Job SummaryThe Wyss Institute is seeking a Scientist I to create and analyze human Bone Marrow Chips that will fly alongside astronaut crewmembers on upcoming lunar space missions. The project's objectives...


  • Boston, Massachusetts, United States Dana-Farber Cancer Institute (DFCI) Full time

    Postdoctoral Research Fellow – Insco LabDana-Farber Cancer InstituteBoston, MAFull TimeA Post-Doctoral position is available to join the Insco Laboratory in the Department of Medical Oncology at Dana-Farber Cancer Institute. We are looking for an enthusiastic scientist to join our team This role offers an unusual opportunity to contribute to a new...


  • Boston, Massachusetts, United States Elektrofi Full time

    Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously biologic therapies by enabling convenient at-home subcutaneous self-administration.Elektrofi is looking for a Translational Scientist/ Senior Scientist to support the development of the novel Elektrofi formulation platform.The...


  • Boston, Massachusetts, United States Caris Life Sciences Full time

    Position SummaryWe are seeking a Principal Scientist to join the Data Science unit at our Cambridge, MA office to develop and leverage innovative computational biology algorithms supporting translational research use of Caris' large-scale multi-omics data.The scientist will work closely with our Data Science, Software Engineering, and Laboratory R&D teams to...


  • Boston, Massachusetts, United States Massachusetts General Physicians Organization Full time

    Job Description – Research Scientist, Cancer Center ()Unique opportunity to join an interdisciplinary team at the Krantz Family Center for Cancer Research at the Massachusetts General Hospital. The Lawrence Lab seeks an experienced candidate to join a team of computational biologists working at the forefront of cancer research and treatment. We use...


  • Boston, Massachusetts, United States Manifold Bio Full time

    Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding...

  • data scientist

    3 months ago


    Boston, Massachusetts, United States Tangle Systems LLC Full time

    Tangle System has an immediate requirement for Data Scientist in Boston MAThe AIML (Artificial Intelligence and Machine Learning) team contributes to the vitality and growth of the organization through researching and building complex cutting edge and scalable AI algorithms models platforms and technologies to significantly improve customer experience and...

  • Data Scientist

    2 months ago


    Boston, Massachusetts, United States Tempus AI Full time

    Passionate about precision medicine and advancing the healthcare industry?Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical...


  • Boston, Massachusetts, United States Verve Therapeutics, Inc. Full time

    Job OverviewCompany OverviewVerve Therapeutics, Inc. is a pioneering clinical-stage company focused on genetic medicine aimed at addressing the global health crisis of cardiovascular disease. Established by leading experts in cardiovascular health, human genetics, and gene-editing, Verve is at the forefront of transforming the treatment landscape from...


  • Boston, Massachusetts, United States Manifold Bio Full time

    Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering.Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process.We combine this and other high-throughput protein engineering...


  • Boston, Massachusetts, United States SOPHiA GENETICS Full time

    Do you have a passion to be at the heart of diagnostic innovation? Use your technical knowledge of Genomics and Next-Generation Sequencing (NGS) workflows coupled with a best-in-class customer focus to onboard new organizations onto the SOPHiA GENETICS ecosystem as our new Implementation Scientist in North America (NORAM). We believe there is a smarter, more...

  • Principal Scientist

    4 weeks ago


    Boston, Massachusetts, United States GALY Full time

    Principal Scientist / Distinguished Scientist, Cell Biology (Cotton Fiber Development) We are out of time. Change must be immediate. We have to help the world find alternative ways to produce all the same things we love. But better. Using less land, less water, less energy, and making less waste. If you think that sounds like a mission, well, you are right....


  • Boston, Massachusetts, United States Unchained Labs Full time

    Position OverviewApplications Scientist - Life SciencesAre you passionate about the intersection of science and technology? If you possess expertise in Biochemistry or Biophysical sciences, this role could be an excellent fit for you. Join our innovative team and leverage your scientific acumen to enhance the sales and support functions for our cutting-edge...

  • Senior Data Scientist

    1 month ago


    Boston, Massachusetts, United States Chubb Full time

    Job DescriptionSenior Data ScientistThe North America PRS (Personal Risk Services) Data Science team at Chubb is seeking a data scientist with 4+ years of industry experience to join our fast-paced, high-energy team. This team is responsible for building data pipelines and delivering predictive modeling and data science solutions to our business partners...


  • Boston, Massachusetts, United States Manifold Bio Full time

    Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering.Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process.We combine this and other high-throughput protein engineering...


  • Boston, Massachusetts, United States Elektrofi Inc Full time

    Job OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges of traditional intravenous biologic therapies, facilitating convenient...


  • Boston, Massachusetts, United States Elektrofi Inc Full time

    Job OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges associated with traditional intravenous biologic therapies, facilitating...

  • Data Scientist III

    2 weeks ago


    Boston, Massachusetts, United States Chewy Full time

    Are you looking for more than just a job? At Chewy, you'll find yourself on a career path with other amazing humans, like yourself. You'll be part of a culture that values everything that you do, who you are, and the goals you have set for your career. We want to give you the opportunity to grow, earn competitive pay, and be happy while you do it. Sounds...